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The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy

The dietary flavonoid quercetin is ubiquitously distributed in fruits, vegetables, and medicinal herbs. Quercetin has been a focal point in recent years due to its versatile health-promoting benefits and high pharmacological values. It has well documented that quercetin exerts anticancer actions by...

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Autores principales: Wang, Man, Chen, Xinzhe, Yu, Fei, Zhang, Lei, Zhang, Yuan, Chang, Wenguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155922/
https://www.ncbi.nlm.nih.gov/pubmed/35656022
http://dx.doi.org/10.1155/2022/4330681
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author Wang, Man
Chen, Xinzhe
Yu, Fei
Zhang, Lei
Zhang, Yuan
Chang, Wenguang
author_facet Wang, Man
Chen, Xinzhe
Yu, Fei
Zhang, Lei
Zhang, Yuan
Chang, Wenguang
author_sort Wang, Man
collection PubMed
description The dietary flavonoid quercetin is ubiquitously distributed in fruits, vegetables, and medicinal herbs. Quercetin has been a focal point in recent years due to its versatile health-promoting benefits and high pharmacological values. It has well documented that quercetin exerts anticancer actions by inhibiting cell proliferation, inducing apoptosis, and retarding the invasion and metastasis of cancer cells. However, the exact mechanism of quercetin-mediated cancer chemoprevention is still not fully understood. With the advances in high-throughput sequencing technologies, the intricate oncogenic signaling networks have been gradually characterized. Increasing evidence on the close association between noncoding RNA (ncRNAs) and cancer etiopathogenesis emphasizes the potential of ncRNAs as promising molecular targets for cancer treatment. Available experimental studies indicate that quercetin can dominate multiple cancer-associated ncRNAs, hence repressing carcinogenesis and cancer development. Thus, modulation of ncRNAs serves as a key mechanism responsible for the anticancer effects of quercetin. In this review, we focus on the chemopreventive effects of quercetin on cancer pathogenesis by targeting cancer-relevant ncRNAs, supporting the viewpoint that quercetin holds promise as a drug candidate for cancer chemoprevention and chemotherapy. An in-depth comprehension of the interplay between quercetin and ncRNAs in the inhibition of cancer development and progression will raise the possibility of developing this bioactive compound as an anticancer agent that could be highly efficacious and safe in clinical practice.
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spelling pubmed-91559222022-06-01 The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy Wang, Man Chen, Xinzhe Yu, Fei Zhang, Lei Zhang, Yuan Chang, Wenguang Oxid Med Cell Longev Review Article The dietary flavonoid quercetin is ubiquitously distributed in fruits, vegetables, and medicinal herbs. Quercetin has been a focal point in recent years due to its versatile health-promoting benefits and high pharmacological values. It has well documented that quercetin exerts anticancer actions by inhibiting cell proliferation, inducing apoptosis, and retarding the invasion and metastasis of cancer cells. However, the exact mechanism of quercetin-mediated cancer chemoprevention is still not fully understood. With the advances in high-throughput sequencing technologies, the intricate oncogenic signaling networks have been gradually characterized. Increasing evidence on the close association between noncoding RNA (ncRNAs) and cancer etiopathogenesis emphasizes the potential of ncRNAs as promising molecular targets for cancer treatment. Available experimental studies indicate that quercetin can dominate multiple cancer-associated ncRNAs, hence repressing carcinogenesis and cancer development. Thus, modulation of ncRNAs serves as a key mechanism responsible for the anticancer effects of quercetin. In this review, we focus on the chemopreventive effects of quercetin on cancer pathogenesis by targeting cancer-relevant ncRNAs, supporting the viewpoint that quercetin holds promise as a drug candidate for cancer chemoprevention and chemotherapy. An in-depth comprehension of the interplay between quercetin and ncRNAs in the inhibition of cancer development and progression will raise the possibility of developing this bioactive compound as an anticancer agent that could be highly efficacious and safe in clinical practice. Hindawi 2022-05-24 /pmc/articles/PMC9155922/ /pubmed/35656022 http://dx.doi.org/10.1155/2022/4330681 Text en Copyright © 2022 Man Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Man
Chen, Xinzhe
Yu, Fei
Zhang, Lei
Zhang, Yuan
Chang, Wenguang
The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy
title The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy
title_full The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy
title_fullStr The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy
title_full_unstemmed The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy
title_short The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy
title_sort targeting of noncoding rnas by quercetin in cancer prevention and therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155922/
https://www.ncbi.nlm.nih.gov/pubmed/35656022
http://dx.doi.org/10.1155/2022/4330681
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