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Multimodal Imaging Observation in Different Progressive Types of Bietti Crystalline Dystrophy

OBJECTIVE: The aim of the study is to observe the difference in progression between type 1 and type 2 Bietti crystalline dystrophy (BCD) using multimodal imaging. METHODS: A retrospective clinical study was performed with six BCD patients who underwent multimodal imaging twice in Hebei Provincial Ey...

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Autores principales: Zhang, Shengjuan, Wang, Lifei, Wang, Yanhui, Shang, Yanxia, Wang, Xin, Ma, Lizhen, Yang, Zanzhang, Xing, Chen, Peng, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155937/
https://www.ncbi.nlm.nih.gov/pubmed/35655804
http://dx.doi.org/10.1155/2022/7426052
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author Zhang, Shengjuan
Wang, Lifei
Wang, Yanhui
Shang, Yanxia
Wang, Xin
Ma, Lizhen
Yang, Zanzhang
Xing, Chen
Peng, Xiaoyan
author_facet Zhang, Shengjuan
Wang, Lifei
Wang, Yanhui
Shang, Yanxia
Wang, Xin
Ma, Lizhen
Yang, Zanzhang
Xing, Chen
Peng, Xiaoyan
author_sort Zhang, Shengjuan
collection PubMed
description OBJECTIVE: The aim of the study is to observe the difference in progression between type 1 and type 2 Bietti crystalline dystrophy (BCD) using multimodal imaging. METHODS: A retrospective clinical study was performed with six BCD patients who underwent multimodal imaging twice in Hebei Provincial Eye Hospital from October 2015 to December 2020. Multimodal imaging includes color fundus photography, fundus autofluorescence (AF), infrared autofluorescence (IRAF), fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT). The fundus lesion progression difference was observed in 3 patients with type 1 BCD and 3 patients with type 2 BCD. RESULTS: In type 1 BCD, the range of hypoautofluorescence (hypo-AF), hypoinfrared autofluorescence (hypo-IRAF), and hypofluorescence in the posterior pole was enlarged, and FFA showed that the lesions in the posterior pole and periphery extended to the middle periphery. SD-OCT revealed retinal and choroidal thinning, progressive loss of the outer nuclear layer and ellipsoid zone, and reduction of the choroid macrovascular diameter. In type 2 BCD, the range of hypo-AF was enlarged, but there was no significant change in the macula area. The uniform hypo-IRAF in the posterior pole showed no significant change. FFA showed no significant change with the progression of the disease in the macula area and the hypofluorescence around it expanded. SD-OCT revealed no obvious change in the macula area. CONCLUSIONS: The retinal choroid atrophy in the macula area of type 1 BCD continued to worsen, and the choroid great vessels became narrower. The macular lesions of type 2 BCD can remain unchanged for a long time.
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spelling pubmed-91559372022-06-01 Multimodal Imaging Observation in Different Progressive Types of Bietti Crystalline Dystrophy Zhang, Shengjuan Wang, Lifei Wang, Yanhui Shang, Yanxia Wang, Xin Ma, Lizhen Yang, Zanzhang Xing, Chen Peng, Xiaoyan J Ophthalmol Research Article OBJECTIVE: The aim of the study is to observe the difference in progression between type 1 and type 2 Bietti crystalline dystrophy (BCD) using multimodal imaging. METHODS: A retrospective clinical study was performed with six BCD patients who underwent multimodal imaging twice in Hebei Provincial Eye Hospital from October 2015 to December 2020. Multimodal imaging includes color fundus photography, fundus autofluorescence (AF), infrared autofluorescence (IRAF), fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT). The fundus lesion progression difference was observed in 3 patients with type 1 BCD and 3 patients with type 2 BCD. RESULTS: In type 1 BCD, the range of hypoautofluorescence (hypo-AF), hypoinfrared autofluorescence (hypo-IRAF), and hypofluorescence in the posterior pole was enlarged, and FFA showed that the lesions in the posterior pole and periphery extended to the middle periphery. SD-OCT revealed retinal and choroidal thinning, progressive loss of the outer nuclear layer and ellipsoid zone, and reduction of the choroid macrovascular diameter. In type 2 BCD, the range of hypo-AF was enlarged, but there was no significant change in the macula area. The uniform hypo-IRAF in the posterior pole showed no significant change. FFA showed no significant change with the progression of the disease in the macula area and the hypofluorescence around it expanded. SD-OCT revealed no obvious change in the macula area. CONCLUSIONS: The retinal choroid atrophy in the macula area of type 1 BCD continued to worsen, and the choroid great vessels became narrower. The macular lesions of type 2 BCD can remain unchanged for a long time. Hindawi 2022-05-24 /pmc/articles/PMC9155937/ /pubmed/35655804 http://dx.doi.org/10.1155/2022/7426052 Text en Copyright © 2022 Shengjuan Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Shengjuan
Wang, Lifei
Wang, Yanhui
Shang, Yanxia
Wang, Xin
Ma, Lizhen
Yang, Zanzhang
Xing, Chen
Peng, Xiaoyan
Multimodal Imaging Observation in Different Progressive Types of Bietti Crystalline Dystrophy
title Multimodal Imaging Observation in Different Progressive Types of Bietti Crystalline Dystrophy
title_full Multimodal Imaging Observation in Different Progressive Types of Bietti Crystalline Dystrophy
title_fullStr Multimodal Imaging Observation in Different Progressive Types of Bietti Crystalline Dystrophy
title_full_unstemmed Multimodal Imaging Observation in Different Progressive Types of Bietti Crystalline Dystrophy
title_short Multimodal Imaging Observation in Different Progressive Types of Bietti Crystalline Dystrophy
title_sort multimodal imaging observation in different progressive types of bietti crystalline dystrophy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155937/
https://www.ncbi.nlm.nih.gov/pubmed/35655804
http://dx.doi.org/10.1155/2022/7426052
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