A Case of Concurrent Leukocytosis and Systemic Capillary Leak Syndrome Due to Pegfilgrastim

Pegfilgrastim is a granulocyte colony-stimulating factor agent used in patients receiving myelosuppressive therapy with chemotherapy or radiation. Two adverse effects associated with this agent include capillary leak syndrome and leukocytosis. To our knowledge, this is the first case of a patient wh...

Descripción completa

Detalles Bibliográficos
Autores principales: Gotera, Nico, Hasan, Shayee, Shrestha, Pritee, Heleno, Caio, Tesar, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156363/
https://www.ncbi.nlm.nih.gov/pubmed/35663724
http://dx.doi.org/10.7759/cureus.24640
_version_ 1784718436962664448
author Gotera, Nico
Hasan, Shayee
Shrestha, Pritee
Heleno, Caio
Tesar, Amy
author_facet Gotera, Nico
Hasan, Shayee
Shrestha, Pritee
Heleno, Caio
Tesar, Amy
author_sort Gotera, Nico
collection PubMed
description Pegfilgrastim is a granulocyte colony-stimulating factor agent used in patients receiving myelosuppressive therapy with chemotherapy or radiation. Two adverse effects associated with this agent include capillary leak syndrome and leukocytosis. To our knowledge, this is the first case of a patient who developed both systemic capillary leak syndrome and leukocytosis greater than 100,000 cells/µL after receiving pegfilgrastim. This patient received early fluid resuscitation, vasopressor support, and methylprednisolone, which improved her clinical course during hospitalization.
format Online
Article
Text
id pubmed-9156363
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-91563632022-06-02 A Case of Concurrent Leukocytosis and Systemic Capillary Leak Syndrome Due to Pegfilgrastim Gotera, Nico Hasan, Shayee Shrestha, Pritee Heleno, Caio Tesar, Amy Cureus Internal Medicine Pegfilgrastim is a granulocyte colony-stimulating factor agent used in patients receiving myelosuppressive therapy with chemotherapy or radiation. Two adverse effects associated with this agent include capillary leak syndrome and leukocytosis. To our knowledge, this is the first case of a patient who developed both systemic capillary leak syndrome and leukocytosis greater than 100,000 cells/µL after receiving pegfilgrastim. This patient received early fluid resuscitation, vasopressor support, and methylprednisolone, which improved her clinical course during hospitalization. Cureus 2022-05-01 /pmc/articles/PMC9156363/ /pubmed/35663724 http://dx.doi.org/10.7759/cureus.24640 Text en Copyright © 2022, Gotera et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Gotera, Nico
Hasan, Shayee
Shrestha, Pritee
Heleno, Caio
Tesar, Amy
A Case of Concurrent Leukocytosis and Systemic Capillary Leak Syndrome Due to Pegfilgrastim
title A Case of Concurrent Leukocytosis and Systemic Capillary Leak Syndrome Due to Pegfilgrastim
title_full A Case of Concurrent Leukocytosis and Systemic Capillary Leak Syndrome Due to Pegfilgrastim
title_fullStr A Case of Concurrent Leukocytosis and Systemic Capillary Leak Syndrome Due to Pegfilgrastim
title_full_unstemmed A Case of Concurrent Leukocytosis and Systemic Capillary Leak Syndrome Due to Pegfilgrastim
title_short A Case of Concurrent Leukocytosis and Systemic Capillary Leak Syndrome Due to Pegfilgrastim
title_sort case of concurrent leukocytosis and systemic capillary leak syndrome due to pegfilgrastim
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156363/
https://www.ncbi.nlm.nih.gov/pubmed/35663724
http://dx.doi.org/10.7759/cureus.24640
work_keys_str_mv AT goteranico acaseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT hasanshayee acaseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT shresthapritee acaseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT helenocaio acaseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT tesaramy acaseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT goteranico caseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT hasanshayee caseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT shresthapritee caseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT helenocaio caseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim
AT tesaramy caseofconcurrentleukocytosisandsystemiccapillaryleaksyndromeduetopegfilgrastim

Ejemplares similares