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Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial
AIMS: Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156384/ https://www.ncbi.nlm.nih.gov/pubmed/35051281 http://dx.doi.org/10.1093/eurheartj/ehab922 |
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author | Lehtisalo, Jenni Rusanen, Minna Solomon, Alina Antikainen, Riitta Laatikainen, Tiina Peltonen, Markku Strandberg, Timo Tuomilehto, Jaakko Soininen, Hilkka Kivipelto, Miia Ngandu, Tiia |
author_facet | Lehtisalo, Jenni Rusanen, Minna Solomon, Alina Antikainen, Riitta Laatikainen, Tiina Peltonen, Markku Strandberg, Timo Tuomilehto, Jaakko Soininen, Hilkka Kivipelto, Miia Ngandu, Tiia |
author_sort | Lehtisalo, Jenni |
collection | PubMed |
description | AIMS: Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome). METHODS AND RESULTS: FINGER enrolled 1259 individuals aged 60–77 years (ClinicalTrials.gov NCT01041989). They were randomized (1:1) to a 2-year multi-domain intervention with diet, physical and cognitive activity, and vascular monitoring (n = 631), or general health advice (n = 628). National registries provided data on CVD including stroke, transient ischaemic attack (TIA), or coronary heart event. During an average of 7.4 years, 229 participants (18%) had at least one CVD diagnosis: 107 in the intervention group and 122 in the control group. The incidence of cerebrovascular events was lower in the intervention than the control group: hazard ratio (HR) for combined stroke/TIA was 0.71 [95% confidence interval (CI): 0.51–0.99] after adjusting for background characteristics. Hazard ratio for coronary events was 0.84 (CI: 0.56–1.26) and total CVD events 0.80 (95% CI: 0.61–1.04). Among those with history of CVD (n = 145), the incidence of both total CVD events (HR: 0.50, 95% CI: 0.28–0.90) and stroke/TIA (HR: 0.40, 95% CI: 0.20–0.81) was lower in the intervention than the control group. CONCLUSION: A 2-year multi-domain lifestyle intervention among older adults was effective in preventing cerebrovascular events and also total CVD events among those who had history of CVD. |
format | Online Article Text |
id | pubmed-9156384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-91563842022-06-04 Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial Lehtisalo, Jenni Rusanen, Minna Solomon, Alina Antikainen, Riitta Laatikainen, Tiina Peltonen, Markku Strandberg, Timo Tuomilehto, Jaakko Soininen, Hilkka Kivipelto, Miia Ngandu, Tiia Eur Heart J Clinical Research AIMS: Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome). METHODS AND RESULTS: FINGER enrolled 1259 individuals aged 60–77 years (ClinicalTrials.gov NCT01041989). They were randomized (1:1) to a 2-year multi-domain intervention with diet, physical and cognitive activity, and vascular monitoring (n = 631), or general health advice (n = 628). National registries provided data on CVD including stroke, transient ischaemic attack (TIA), or coronary heart event. During an average of 7.4 years, 229 participants (18%) had at least one CVD diagnosis: 107 in the intervention group and 122 in the control group. The incidence of cerebrovascular events was lower in the intervention than the control group: hazard ratio (HR) for combined stroke/TIA was 0.71 [95% confidence interval (CI): 0.51–0.99] after adjusting for background characteristics. Hazard ratio for coronary events was 0.84 (CI: 0.56–1.26) and total CVD events 0.80 (95% CI: 0.61–1.04). Among those with history of CVD (n = 145), the incidence of both total CVD events (HR: 0.50, 95% CI: 0.28–0.90) and stroke/TIA (HR: 0.40, 95% CI: 0.20–0.81) was lower in the intervention than the control group. CONCLUSION: A 2-year multi-domain lifestyle intervention among older adults was effective in preventing cerebrovascular events and also total CVD events among those who had history of CVD. Oxford University Press 2022-01-20 /pmc/articles/PMC9156384/ /pubmed/35051281 http://dx.doi.org/10.1093/eurheartj/ehab922 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clinical Research Lehtisalo, Jenni Rusanen, Minna Solomon, Alina Antikainen, Riitta Laatikainen, Tiina Peltonen, Markku Strandberg, Timo Tuomilehto, Jaakko Soininen, Hilkka Kivipelto, Miia Ngandu, Tiia Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial |
title | Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial |
title_full | Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial |
title_fullStr | Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial |
title_full_unstemmed | Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial |
title_short | Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial |
title_sort | effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the finger trial |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156384/ https://www.ncbi.nlm.nih.gov/pubmed/35051281 http://dx.doi.org/10.1093/eurheartj/ehab922 |
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