STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity

Activation of the innate immune STimulator of INterferon Genes (STING) pathway potentiates antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We conjugated STING-activating cyclic dinucleotides (CDNs) to PEGylated lipids (CDN-PEG-lipids; PEG, polyethylene glycol)...

Descripción completa

Detalles Bibliográficos
Autores principales: Dane, Eric L., Belessiotis-Richards, Alexis, Backlund, Coralie, Wang, Jianing, Hidaka, Kousuke, Milling, Lauren E., Bhagchandani, Sachin, Melo, Mariane B., Wu, Shengwei, Li, Na, Donahue, Nathan, Ni, Kaiyuan, Ma, Leyuan, Okaniwa, Masanori, Stevens, Molly M., Alexander-Katz, Alfredo, Irvine, Darrell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156412/
https://www.ncbi.nlm.nih.gov/pubmed/35606429
http://dx.doi.org/10.1038/s41563-022-01251-z

Ejemplares similares

Ejemplares similares