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Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease
Genetic predisposition through F11R-single-nucleotide variation (SNV) influences circulatory soluble junctional adhesion molecule-A (sJAM-A) levels in coronary artery disease (CAD) patients. Homozygous carriers of the minor alleles (F11R-SNVs rs2774276, rs790056) show enhanced levels of thrombo-infl...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156439/ https://www.ncbi.nlm.nih.gov/pubmed/35663628 http://dx.doi.org/10.1016/j.jacbts.2022.03.003 |
| _version_ | 1784718452199522304 |
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| author | Rath, Dominik Rapp, Vera Schwartz, Jessica Winter, Stefan Emschermann, Frederic Arnold, Daniel Rheinlaender, Johannes Büttcher, Manuela Strebl, Michael Braun, Michael B. Altgelt, Konstanze Uribe, Álvaro Petersen Schories, Christoph Canjuga, Denis Schaeffeler, Elke Borst, Oliver Schäffer, Tilman E. Langer, Harald Stehle, Thilo Schwab, Matthias Geisler, Tobias Gawaz, Meinrad Chatterjee, Madhumita |
| author_facet | Rath, Dominik Rapp, Vera Schwartz, Jessica Winter, Stefan Emschermann, Frederic Arnold, Daniel Rheinlaender, Johannes Büttcher, Manuela Strebl, Michael Braun, Michael B. Altgelt, Konstanze Uribe, Álvaro Petersen Schories, Christoph Canjuga, Denis Schaeffeler, Elke Borst, Oliver Schäffer, Tilman E. Langer, Harald Stehle, Thilo Schwab, Matthias Geisler, Tobias Gawaz, Meinrad Chatterjee, Madhumita |
| author_sort | Rath, Dominik |
| collection | PubMed |
| description | Genetic predisposition through F11R-single-nucleotide variation (SNV) influences circulatory soluble junctional adhesion molecule-A (sJAM-A) levels in coronary artery disease (CAD) patients. Homozygous carriers of the minor alleles (F11R-SNVs rs2774276, rs790056) show enhanced levels of thrombo-inflammatory sJAM-A. Both F11R-SNVs and sJAM-A are associated with worse prognosis for recurrent myocardial infarction in CAD patients. Platelet surface-associated JAM-A correlate with platelet activation markers in CAD patients. Activated platelets shed transmembrane-JAM-A, generating proinflammatory sJAM-A and JAM-A-bearing microparticles. Platelet transmembrane-JAM-A and sJAM-A as homophilic interaction partners exaggerate thrombotic and thrombo-inflammatory platelet monocyte interactions. Therapeutic strategies interfering with this homophilic interface may regulate thrombotic and thrombo-inflammatory platelet response in cardiovascular pathologies where circulatory sJAM-A levels are elevated. |
| format | Online Article Text |
| id | pubmed-9156439 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91564392022-06-02 Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease Rath, Dominik Rapp, Vera Schwartz, Jessica Winter, Stefan Emschermann, Frederic Arnold, Daniel Rheinlaender, Johannes Büttcher, Manuela Strebl, Michael Braun, Michael B. Altgelt, Konstanze Uribe, Álvaro Petersen Schories, Christoph Canjuga, Denis Schaeffeler, Elke Borst, Oliver Schäffer, Tilman E. Langer, Harald Stehle, Thilo Schwab, Matthias Geisler, Tobias Gawaz, Meinrad Chatterjee, Madhumita JACC Basic Transl Sci Leading Edge Translational Research Genetic predisposition through F11R-single-nucleotide variation (SNV) influences circulatory soluble junctional adhesion molecule-A (sJAM-A) levels in coronary artery disease (CAD) patients. Homozygous carriers of the minor alleles (F11R-SNVs rs2774276, rs790056) show enhanced levels of thrombo-inflammatory sJAM-A. Both F11R-SNVs and sJAM-A are associated with worse prognosis for recurrent myocardial infarction in CAD patients. Platelet surface-associated JAM-A correlate with platelet activation markers in CAD patients. Activated platelets shed transmembrane-JAM-A, generating proinflammatory sJAM-A and JAM-A-bearing microparticles. Platelet transmembrane-JAM-A and sJAM-A as homophilic interaction partners exaggerate thrombotic and thrombo-inflammatory platelet monocyte interactions. Therapeutic strategies interfering with this homophilic interface may regulate thrombotic and thrombo-inflammatory platelet response in cardiovascular pathologies where circulatory sJAM-A levels are elevated. Elsevier 2022-05-23 /pmc/articles/PMC9156439/ /pubmed/35663628 http://dx.doi.org/10.1016/j.jacbts.2022.03.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Leading Edge Translational Research Rath, Dominik Rapp, Vera Schwartz, Jessica Winter, Stefan Emschermann, Frederic Arnold, Daniel Rheinlaender, Johannes Büttcher, Manuela Strebl, Michael Braun, Michael B. Altgelt, Konstanze Uribe, Álvaro Petersen Schories, Christoph Canjuga, Denis Schaeffeler, Elke Borst, Oliver Schäffer, Tilman E. Langer, Harald Stehle, Thilo Schwab, Matthias Geisler, Tobias Gawaz, Meinrad Chatterjee, Madhumita Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease |
| title | Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease |
| title_full | Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease |
| title_fullStr | Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease |
| title_full_unstemmed | Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease |
| title_short | Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease |
| title_sort | homophilic interaction between transmembrane-jam-a and soluble jam-a regulates thrombo-inflammation: implications for coronary artery disease |
| topic | Leading Edge Translational Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156439/ https://www.ncbi.nlm.nih.gov/pubmed/35663628 http://dx.doi.org/10.1016/j.jacbts.2022.03.003 |
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