Lipid metabolism is dysregulated in a mouse model of diabetes

Much evidence for diabetes mellitus being associated with dysregulated lipid metabolism has been accrued from studies using blood plasma. However, the systemic dysregulation these results point to is not understood. This study used Lipid Traffic Analysis on data from a mouse model of diabetes to tes...

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Autor principal: Furse, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156495/
https://www.ncbi.nlm.nih.gov/pubmed/35641694
http://dx.doi.org/10.1007/s11306-022-01884-w
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author Furse, Samuel
author_facet Furse, Samuel
author_sort Furse, Samuel
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description Much evidence for diabetes mellitus being associated with dysregulated lipid metabolism has been accrued from studies using blood plasma. However, the systemic dysregulation these results point to is not understood. This study used Lipid Traffic Analysis on data from a mouse model of diabetes to test the hypothesis that the systemic control of lipid metabolism differed in a model of diabetes. This provided eidence for changes in the systemic control of both triglyceride and phospholipid metabolism that were not attributable to dietary intake. This supports the conclusion that diabetes is a systemic condition associated with dysregulated lipid metabolism through several pathways. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11306-022-01884-w.
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spelling pubmed-91564952022-06-02 Lipid metabolism is dysregulated in a mouse model of diabetes Furse, Samuel Metabolomics Short Communication Much evidence for diabetes mellitus being associated with dysregulated lipid metabolism has been accrued from studies using blood plasma. However, the systemic dysregulation these results point to is not understood. This study used Lipid Traffic Analysis on data from a mouse model of diabetes to test the hypothesis that the systemic control of lipid metabolism differed in a model of diabetes. This provided eidence for changes in the systemic control of both triglyceride and phospholipid metabolism that were not attributable to dietary intake. This supports the conclusion that diabetes is a systemic condition associated with dysregulated lipid metabolism through several pathways. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11306-022-01884-w. Springer US 2022-05-31 2022 /pmc/articles/PMC9156495/ /pubmed/35641694 http://dx.doi.org/10.1007/s11306-022-01884-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Furse, Samuel
Lipid metabolism is dysregulated in a mouse model of diabetes
title Lipid metabolism is dysregulated in a mouse model of diabetes
title_full Lipid metabolism is dysregulated in a mouse model of diabetes
title_fullStr Lipid metabolism is dysregulated in a mouse model of diabetes
title_full_unstemmed Lipid metabolism is dysregulated in a mouse model of diabetes
title_short Lipid metabolism is dysregulated in a mouse model of diabetes
title_sort lipid metabolism is dysregulated in a mouse model of diabetes
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156495/
https://www.ncbi.nlm.nih.gov/pubmed/35641694
http://dx.doi.org/10.1007/s11306-022-01884-w
work_keys_str_mv AT fursesamuel lipidmetabolismisdysregulatedinamousemodelofdiabetes

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