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A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors

Magnetic Resonance (MR) Imaging-guided High Intensity focused Ultrasound (MRgHIFU) is a non-invasive, non-ionizing thermal ablation therapy that is particularly interesting for the palliative or curative treatment of musculoskeletal tumors. We introduce a new modular MRgHIFU device that allows the u...

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Autores principales: Cabras, Paolo, Auloge, Pierre, Bing, Fabrice, Rao, Pramod Prabhakar, Hoarau, Stéphanie, Dumont, Erik, Durand, Alexandre, Maurin, Benjamin, Wach, Benoit, Cuvillon, Loïc, Breton, Elodie, Gangi, Afshin, Vappou, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156664/
https://www.ncbi.nlm.nih.gov/pubmed/35641597
http://dx.doi.org/10.1038/s41598-022-13213-1
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author Cabras, Paolo
Auloge, Pierre
Bing, Fabrice
Rao, Pramod Prabhakar
Hoarau, Stéphanie
Dumont, Erik
Durand, Alexandre
Maurin, Benjamin
Wach, Benoit
Cuvillon, Loïc
Breton, Elodie
Gangi, Afshin
Vappou, Jonathan
author_facet Cabras, Paolo
Auloge, Pierre
Bing, Fabrice
Rao, Pramod Prabhakar
Hoarau, Stéphanie
Dumont, Erik
Durand, Alexandre
Maurin, Benjamin
Wach, Benoit
Cuvillon, Loïc
Breton, Elodie
Gangi, Afshin
Vappou, Jonathan
author_sort Cabras, Paolo
collection PubMed
description Magnetic Resonance (MR) Imaging-guided High Intensity focused Ultrasound (MRgHIFU) is a non-invasive, non-ionizing thermal ablation therapy that is particularly interesting for the palliative or curative treatment of musculoskeletal tumors. We introduce a new modular MRgHIFU device that allows the ultrasound transducer to be positioned precisely and interactively over the body part to be treated. A flexible, MR-compatible supporting structure allows free positioning of the transducer under MRI/optical fusion imaging guidance. The same structure can be rigidified using pneumatic depression, holding the transducer rigidly in place. Targeting accuracy was first evaluated in vitro. The average targeting error of the complete process was found to be equal to 5.4 ± 2.2 mm in terms of focus position, and 4.7° ± 2° in terms of transducer orientation. First-in-man feasibility is demonstrated on a patient suffering from important, uncontrolled pain from a bone metastasis located in the forearm. The 81 × 47 × 34 mm(3) lesion was successfully treated using five successive positions of the transducer, under real-time monitoring by MR Thermometry. Significant pain palliation was observed 3 days after the intervention. The system described and characterized in this study is a particularly interesting modular, low-cost MRgHIFU device for musculoskeletal tumor therapy.
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spelling pubmed-91566642022-06-02 A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors Cabras, Paolo Auloge, Pierre Bing, Fabrice Rao, Pramod Prabhakar Hoarau, Stéphanie Dumont, Erik Durand, Alexandre Maurin, Benjamin Wach, Benoit Cuvillon, Loïc Breton, Elodie Gangi, Afshin Vappou, Jonathan Sci Rep Article Magnetic Resonance (MR) Imaging-guided High Intensity focused Ultrasound (MRgHIFU) is a non-invasive, non-ionizing thermal ablation therapy that is particularly interesting for the palliative or curative treatment of musculoskeletal tumors. We introduce a new modular MRgHIFU device that allows the ultrasound transducer to be positioned precisely and interactively over the body part to be treated. A flexible, MR-compatible supporting structure allows free positioning of the transducer under MRI/optical fusion imaging guidance. The same structure can be rigidified using pneumatic depression, holding the transducer rigidly in place. Targeting accuracy was first evaluated in vitro. The average targeting error of the complete process was found to be equal to 5.4 ± 2.2 mm in terms of focus position, and 4.7° ± 2° in terms of transducer orientation. First-in-man feasibility is demonstrated on a patient suffering from important, uncontrolled pain from a bone metastasis located in the forearm. The 81 × 47 × 34 mm(3) lesion was successfully treated using five successive positions of the transducer, under real-time monitoring by MR Thermometry. Significant pain palliation was observed 3 days after the intervention. The system described and characterized in this study is a particularly interesting modular, low-cost MRgHIFU device for musculoskeletal tumor therapy. Nature Publishing Group UK 2022-05-31 /pmc/articles/PMC9156664/ /pubmed/35641597 http://dx.doi.org/10.1038/s41598-022-13213-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cabras, Paolo
Auloge, Pierre
Bing, Fabrice
Rao, Pramod Prabhakar
Hoarau, Stéphanie
Dumont, Erik
Durand, Alexandre
Maurin, Benjamin
Wach, Benoit
Cuvillon, Loïc
Breton, Elodie
Gangi, Afshin
Vappou, Jonathan
A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors
title A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors
title_full A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors
title_fullStr A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors
title_full_unstemmed A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors
title_short A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors
title_sort new versatile mr-guided high-intensity focused ultrasound (hifu) device for the treatment of musculoskeletal tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156664/
https://www.ncbi.nlm.nih.gov/pubmed/35641597
http://dx.doi.org/10.1038/s41598-022-13213-1
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