Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis

Atherosclerosis is a maladaptive chronic inflammatory disease, which remains the leading cause of death worldwide. The NLRP3 inflammasome constitutes a major driver of atherosclerosis, yet the mechanism of action is poorly understood. Mitochondrial dysfunction is essential for NLRP3 inflammasome act...

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Detalles Bibliográficos
Autores principales: Jin, Ying, Liu, Yao, Xu, Lei, Xu, Jie, Xiong, Yulian, Peng, Yazhi, Ding, Ke, Zheng, Shuang, Yang, Nan, Zhang, Zemei, Li, Lin, Tan, Liguo, Song, HongXian, Fu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156694/
https://www.ncbi.nlm.nih.gov/pubmed/35641492
http://dx.doi.org/10.1038/s41419-022-04966-8

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