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Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots

In this work, we report, the synthesis of Boron and Sulfur co-doped graphene quantum dots (BS-GQDs) and its applicability as a label-free fluorescence sensing probe for the highly sensitive and selective detection of dopamine (DA). Upon addition of DA, the fluorescence intensity of BS-GQDs were effe...

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Autores principales: Chatterjee, Manisha, Nath, Prathul, Kadian, Sachin, Kumar, Anshu, Kumar, Vishal, Roy, Partha, Manik, Gaurav, Satapathi, Soumitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156697/
https://www.ncbi.nlm.nih.gov/pubmed/35641637
http://dx.doi.org/10.1038/s41598-022-13016-4
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author Chatterjee, Manisha
Nath, Prathul
Kadian, Sachin
Kumar, Anshu
Kumar, Vishal
Roy, Partha
Manik, Gaurav
Satapathi, Soumitra
author_facet Chatterjee, Manisha
Nath, Prathul
Kadian, Sachin
Kumar, Anshu
Kumar, Vishal
Roy, Partha
Manik, Gaurav
Satapathi, Soumitra
author_sort Chatterjee, Manisha
collection PubMed
description In this work, we report, the synthesis of Boron and Sulfur co-doped graphene quantum dots (BS-GQDs) and its applicability as a label-free fluorescence sensing probe for the highly sensitive and selective detection of dopamine (DA). Upon addition of DA, the fluorescence intensity of BS-GQDs were effectively quenched over a wide concentration range of DA (0–340 μM) with an ultra-low detection limit of 3.6 μM. The quenching mechanism involved photoinduced electron transfer process from BS-GQDs to dopamine-quinone, produced by the oxidization of DA under alkaline conditions. The proposed sensing mechanism was probed using a detailed study of UV–Vis absorbance, steady state and time resolved fluorescence spectroscopy. The high selectivity of the fluorescent sensor towards DA is established. Our study opens up the possibility of designing a low-cost biosensor which will be suitable for detecting DA in real samples.
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spelling pubmed-91566972022-06-02 Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots Chatterjee, Manisha Nath, Prathul Kadian, Sachin Kumar, Anshu Kumar, Vishal Roy, Partha Manik, Gaurav Satapathi, Soumitra Sci Rep Article In this work, we report, the synthesis of Boron and Sulfur co-doped graphene quantum dots (BS-GQDs) and its applicability as a label-free fluorescence sensing probe for the highly sensitive and selective detection of dopamine (DA). Upon addition of DA, the fluorescence intensity of BS-GQDs were effectively quenched over a wide concentration range of DA (0–340 μM) with an ultra-low detection limit of 3.6 μM. The quenching mechanism involved photoinduced electron transfer process from BS-GQDs to dopamine-quinone, produced by the oxidization of DA under alkaline conditions. The proposed sensing mechanism was probed using a detailed study of UV–Vis absorbance, steady state and time resolved fluorescence spectroscopy. The high selectivity of the fluorescent sensor towards DA is established. Our study opens up the possibility of designing a low-cost biosensor which will be suitable for detecting DA in real samples. Nature Publishing Group UK 2022-05-31 /pmc/articles/PMC9156697/ /pubmed/35641637 http://dx.doi.org/10.1038/s41598-022-13016-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chatterjee, Manisha
Nath, Prathul
Kadian, Sachin
Kumar, Anshu
Kumar, Vishal
Roy, Partha
Manik, Gaurav
Satapathi, Soumitra
Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots
title Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots
title_full Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots
title_fullStr Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots
title_full_unstemmed Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots
title_short Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots
title_sort highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156697/
https://www.ncbi.nlm.nih.gov/pubmed/35641637
http://dx.doi.org/10.1038/s41598-022-13016-4
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