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Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy
In patients with diabetes, it has been suggested that physical exercise may reduce albuminuria and the progression of renal disease. However, the molecular mechanism by which physical exercise protects the kidney in diabetes remains poorly understood. The aim of the present study was to determine th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156698/ https://www.ncbi.nlm.nih.gov/pubmed/35641586 http://dx.doi.org/10.1038/s41598-022-13054-y |
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author | Formigari, Guilherme Pedron Dátilo, Marcella Neves Vareda, Beatriz Bonfante, Ivan Luiz Padilha Cavaglieri, Claudia Regina Lopes de Faria, Jacqueline M. Lopes de Faria, José B. |
author_facet | Formigari, Guilherme Pedron Dátilo, Marcella Neves Vareda, Beatriz Bonfante, Ivan Luiz Padilha Cavaglieri, Claudia Regina Lopes de Faria, Jacqueline M. Lopes de Faria, José B. |
author_sort | Formigari, Guilherme Pedron |
collection | PubMed |
description | In patients with diabetes, it has been suggested that physical exercise may reduce albuminuria and the progression of renal disease. However, the molecular mechanism by which physical exercise protects the kidney in diabetes remains poorly understood. The aim of the present study was to determine the contribution of muscle irisin secretion induced by aerobic physical exercise with the subsequent activation of AMPK for kidney protection under diabetic conditions. Aerobic physical exercise in rats protected the kidney in streptozotocin-induced diabetes. It reduced albuminuria, glomerular hypertrophy, and glomerular expression of collagen IV and fibronectin, as well as markers of kidney inflammation, when compared to sedentary diabetic rats. These effects were associated with elevation in muscle FNDC5/irisin and activity of AMPK in the diabetic kidney. However, the beneficial effects of exercise were lost when the diabetic rats were treated with CycloRGDyK, that in the bone it has been described as an irisin receptor blocker. In cultured human tubular (HK-2) cells, treatment with recombinant irisin counteracted the effect of high glucose in a dose-dependent manner. Irisin, per se, also activated AMPK in HK-2 cells. It is concluded that in diabetes, the renal protective effect of exercise may be mediated by the irisin/AMPK pathway. |
format | Online Article Text |
id | pubmed-9156698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91566982022-06-02 Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy Formigari, Guilherme Pedron Dátilo, Marcella Neves Vareda, Beatriz Bonfante, Ivan Luiz Padilha Cavaglieri, Claudia Regina Lopes de Faria, Jacqueline M. Lopes de Faria, José B. Sci Rep Article In patients with diabetes, it has been suggested that physical exercise may reduce albuminuria and the progression of renal disease. However, the molecular mechanism by which physical exercise protects the kidney in diabetes remains poorly understood. The aim of the present study was to determine the contribution of muscle irisin secretion induced by aerobic physical exercise with the subsequent activation of AMPK for kidney protection under diabetic conditions. Aerobic physical exercise in rats protected the kidney in streptozotocin-induced diabetes. It reduced albuminuria, glomerular hypertrophy, and glomerular expression of collagen IV and fibronectin, as well as markers of kidney inflammation, when compared to sedentary diabetic rats. These effects were associated with elevation in muscle FNDC5/irisin and activity of AMPK in the diabetic kidney. However, the beneficial effects of exercise were lost when the diabetic rats were treated with CycloRGDyK, that in the bone it has been described as an irisin receptor blocker. In cultured human tubular (HK-2) cells, treatment with recombinant irisin counteracted the effect of high glucose in a dose-dependent manner. Irisin, per se, also activated AMPK in HK-2 cells. It is concluded that in diabetes, the renal protective effect of exercise may be mediated by the irisin/AMPK pathway. Nature Publishing Group UK 2022-05-31 /pmc/articles/PMC9156698/ /pubmed/35641586 http://dx.doi.org/10.1038/s41598-022-13054-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Formigari, Guilherme Pedron Dátilo, Marcella Neves Vareda, Beatriz Bonfante, Ivan Luiz Padilha Cavaglieri, Claudia Regina Lopes de Faria, Jacqueline M. Lopes de Faria, José B. Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy |
title | Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy |
title_full | Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy |
title_fullStr | Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy |
title_full_unstemmed | Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy |
title_short | Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy |
title_sort | renal protection induced by physical exercise may be mediated by the irisin/ampk axis in diabetic nephropathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156698/ https://www.ncbi.nlm.nih.gov/pubmed/35641586 http://dx.doi.org/10.1038/s41598-022-13054-y |
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