Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3(SPOP) E3 ligase in cancer cells

Abnormal neddylation activation is frequently observed in human cancers and neddylation inhibition has been proposed as a therapy for cancer. Here, we report that MLN4924, a small-molecule inhibitor of neddylation activating enzyme, increases glutamine uptake in breast cancer cells by causing accumu...

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Detalles Bibliográficos
Autores principales: Zhou, Qiyin, Lin, Wenyu, Wang, Chaoqun, Sun, Fei, Ju, Siwei, Chen, Qian, Wang, Yi, Chen, Yongxia, Li, Haomin, Wang, Linbo, Hu, Zeping, Jin, Hongchuan, Wang, Xian, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156729/
https://www.ncbi.nlm.nih.gov/pubmed/35641493
http://dx.doi.org/10.1038/s41467-022-30559-2

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