Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure

The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca(2+) ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling. While phospholamban is a bona-fide therapeutic target, approaches to selec...

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Detalles Bibliográficos
Autores principales: De Genst, Erwin, Foo, Kylie S., Xiao, Yao, Rohner, Eduarde, de Vries, Emma, Sohlmér, Jesper, Witman, Nevin, Hidalgo, Alejandro, Kolstad, Terje R. S., Louch, William E., Pehrsson, Susanne, Park, Andrew, Ikeda, Yasuhiro, Li, Xidan, Mayr, Lorenz M., Wickson, Kate, Jennbacken, Karin, Hansson, Kenny, Fritsche-Danielson, Regina, Hunt, James, Chien, Kenneth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156741/
https://www.ncbi.nlm.nih.gov/pubmed/35641497
http://dx.doi.org/10.1038/s41467-022-29703-9

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