Cargando…

HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria

Globally, malaria and human immunodeficiency virus (HIV) are both independently associated with a massive burden of disease and death. While their co-infection has been well studied for Plasmodium falciparum, scarce data exist regarding the association of P. vivax and HIV. In this cohort study, we a...

Descripción completa

Detalles Bibliográficos
Autores principales: Guerra, Cecilia Victoria Caraballo, da Silva, Bernardo Maia, Müller, Pia, Baia-da-Silva, Djane Clarys, Moura, Marco Antônio Saboia, Araújo, José Deney Alves, Silva, Juan Carlo Santos e, Silva-Neto, Alexandre Vilhena, da Silva Balieiro, Antonio Alcirley, da Costa-Martins, André Guilherme, Melo, Gisely Cardoso, Val, Fernando, Bassat, Quique, Nakaya, Helder I., Martinez-Espinosa, Flor Ernestina, Lacerda, Marcus, Sampaio, Vanderson Souza, Monteiro, Wuelton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156757/
https://www.ncbi.nlm.nih.gov/pubmed/35641592
http://dx.doi.org/10.1038/s41598-022-13256-4
_version_ 1784718502269026304
author Guerra, Cecilia Victoria Caraballo
da Silva, Bernardo Maia
Müller, Pia
Baia-da-Silva, Djane Clarys
Moura, Marco Antônio Saboia
Araújo, José Deney Alves
Silva, Juan Carlo Santos e
Silva-Neto, Alexandre Vilhena
da Silva Balieiro, Antonio Alcirley
da Costa-Martins, André Guilherme
Melo, Gisely Cardoso
Val, Fernando
Bassat, Quique
Nakaya, Helder I.
Martinez-Espinosa, Flor Ernestina
Lacerda, Marcus
Sampaio, Vanderson Souza
Monteiro, Wuelton
author_facet Guerra, Cecilia Victoria Caraballo
da Silva, Bernardo Maia
Müller, Pia
Baia-da-Silva, Djane Clarys
Moura, Marco Antônio Saboia
Araújo, José Deney Alves
Silva, Juan Carlo Santos e
Silva-Neto, Alexandre Vilhena
da Silva Balieiro, Antonio Alcirley
da Costa-Martins, André Guilherme
Melo, Gisely Cardoso
Val, Fernando
Bassat, Quique
Nakaya, Helder I.
Martinez-Espinosa, Flor Ernestina
Lacerda, Marcus
Sampaio, Vanderson Souza
Monteiro, Wuelton
author_sort Guerra, Cecilia Victoria Caraballo
collection PubMed
description Globally, malaria and human immunodeficiency virus (HIV) are both independently associated with a massive burden of disease and death. While their co-infection has been well studied for Plasmodium falciparum, scarce data exist regarding the association of P. vivax and HIV. In this cohort study, we assessed the effect of HIV on the risk of vivax malaria infection and recurrence during a 4-year follow-up period in an endemic area of the Brazilian Amazon. For the purpose of this study, we obtained clinical information from January 2012 to December 2016 from two databases. HIV screening data were acquired from the clinical information system at the tropical hospital Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD). The National Malaria Surveillance database (SIVEP malaria) was utilized to identify malaria infections during a 4-year follow-up period after diagnosis of HIV. Both datasets were combined via data linkage. Between 2012 and 2016, a total of 42,121 people were screened for HIV, with 1569 testing positive (3.7%). Out of all the patients diagnosed with HIV, 198 had at least one episode of P. vivax malaria in the follow-up. In the HIV-negative group, 711 participants had at least one P. vivax malaria episode. When comparing both groups, HIV patients had a 6.48 [(5.37–7.83); P < 0.0001] (adjusted relative risk) greater chance of acquiring P. vivax malaria. Moreover, being of the male gender [ARR = 1.41 (1.17–1.71); P < 0.0001], Amerindian ethnicity [ARR = 2.77 (1.46–5.28); P < 0.0001], and a resident in a municipality of the Metropolitan region of Manaus [ARR = 1.48 (1.02–2.15); P = 0.038] were independent risk factors associated with an increased risk of clinical malaria. Education ≥ 8 years [ARR = 0.41 (0.26–0.64); P < 0.0001] and living in the urban area [ARR = 0.44 (0.24–0.80); P = 0.007] were associated to a lower risk of P. vivax malaria. A total of 28 (14.1%) and 180 (25.3%) recurrences (at least a second clinical malaria episode) were reported in the HIV-positive and HIV-negative groups, respectively. After adjusting for sex and education, HIV-positive status was associated with a tendency towards protection from P. vivax malaria recurrences [ARR = 0.55 (0.27–1.10); P = 0.090]. HIV status was not associated with hospitalizations due to P. vivax malaria. CD4 + counts and viral load were not associated with recurrences of P. vivax malaria. No significant differences were found in the distribution of parasitemia between HIV-negative and HIV-positive P. vivax malaria patients. Our results suggest that HIV-positive status is a risk factor for vivax malaria infection, which represents an additional challenge that should be addressed during elimination efforts.
format Online
Article
Text
id pubmed-9156757
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-91567572022-06-02 HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria Guerra, Cecilia Victoria Caraballo da Silva, Bernardo Maia Müller, Pia Baia-da-Silva, Djane Clarys Moura, Marco Antônio Saboia Araújo, José Deney Alves Silva, Juan Carlo Santos e Silva-Neto, Alexandre Vilhena da Silva Balieiro, Antonio Alcirley da Costa-Martins, André Guilherme Melo, Gisely Cardoso Val, Fernando Bassat, Quique Nakaya, Helder I. Martinez-Espinosa, Flor Ernestina Lacerda, Marcus Sampaio, Vanderson Souza Monteiro, Wuelton Sci Rep Article Globally, malaria and human immunodeficiency virus (HIV) are both independently associated with a massive burden of disease and death. While their co-infection has been well studied for Plasmodium falciparum, scarce data exist regarding the association of P. vivax and HIV. In this cohort study, we assessed the effect of HIV on the risk of vivax malaria infection and recurrence during a 4-year follow-up period in an endemic area of the Brazilian Amazon. For the purpose of this study, we obtained clinical information from January 2012 to December 2016 from two databases. HIV screening data were acquired from the clinical information system at the tropical hospital Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD). The National Malaria Surveillance database (SIVEP malaria) was utilized to identify malaria infections during a 4-year follow-up period after diagnosis of HIV. Both datasets were combined via data linkage. Between 2012 and 2016, a total of 42,121 people were screened for HIV, with 1569 testing positive (3.7%). Out of all the patients diagnosed with HIV, 198 had at least one episode of P. vivax malaria in the follow-up. In the HIV-negative group, 711 participants had at least one P. vivax malaria episode. When comparing both groups, HIV patients had a 6.48 [(5.37–7.83); P < 0.0001] (adjusted relative risk) greater chance of acquiring P. vivax malaria. Moreover, being of the male gender [ARR = 1.41 (1.17–1.71); P < 0.0001], Amerindian ethnicity [ARR = 2.77 (1.46–5.28); P < 0.0001], and a resident in a municipality of the Metropolitan region of Manaus [ARR = 1.48 (1.02–2.15); P = 0.038] were independent risk factors associated with an increased risk of clinical malaria. Education ≥ 8 years [ARR = 0.41 (0.26–0.64); P < 0.0001] and living in the urban area [ARR = 0.44 (0.24–0.80); P = 0.007] were associated to a lower risk of P. vivax malaria. A total of 28 (14.1%) and 180 (25.3%) recurrences (at least a second clinical malaria episode) were reported in the HIV-positive and HIV-negative groups, respectively. After adjusting for sex and education, HIV-positive status was associated with a tendency towards protection from P. vivax malaria recurrences [ARR = 0.55 (0.27–1.10); P = 0.090]. HIV status was not associated with hospitalizations due to P. vivax malaria. CD4 + counts and viral load were not associated with recurrences of P. vivax malaria. No significant differences were found in the distribution of parasitemia between HIV-negative and HIV-positive P. vivax malaria patients. Our results suggest that HIV-positive status is a risk factor for vivax malaria infection, which represents an additional challenge that should be addressed during elimination efforts. Nature Publishing Group UK 2022-05-31 /pmc/articles/PMC9156757/ /pubmed/35641592 http://dx.doi.org/10.1038/s41598-022-13256-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Guerra, Cecilia Victoria Caraballo
da Silva, Bernardo Maia
Müller, Pia
Baia-da-Silva, Djane Clarys
Moura, Marco Antônio Saboia
Araújo, José Deney Alves
Silva, Juan Carlo Santos e
Silva-Neto, Alexandre Vilhena
da Silva Balieiro, Antonio Alcirley
da Costa-Martins, André Guilherme
Melo, Gisely Cardoso
Val, Fernando
Bassat, Quique
Nakaya, Helder I.
Martinez-Espinosa, Flor Ernestina
Lacerda, Marcus
Sampaio, Vanderson Souza
Monteiro, Wuelton
HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria
title HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria
title_full HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria
title_fullStr HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria
title_full_unstemmed HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria
title_short HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria
title_sort hiv infection increases the risk of acquiring plasmodium vivax malaria: a 4-year cohort study in the brazilian amazon hiv and risk of vivax malaria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156757/
https://www.ncbi.nlm.nih.gov/pubmed/35641592
http://dx.doi.org/10.1038/s41598-022-13256-4
work_keys_str_mv AT guerraceciliavictoriacaraballo hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT dasilvabernardomaia hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT mullerpia hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT baiadasilvadjaneclarys hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT mouramarcoantoniosaboia hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT araujojosedeneyalves hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT silvajuancarlosantose hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT silvanetoalexandrevilhena hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT dasilvabalieiroantonioalcirley hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT dacostamartinsandreguilherme hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT melogiselycardoso hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT valfernando hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT bassatquique hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT nakayahelderi hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT martinezespinosaflorernestina hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT lacerdamarcus hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT sampaiovandersonsouza hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria
AT monteirowuelton hivinfectionincreasestheriskofacquiringplasmodiumvivaxmalariaa4yearcohortstudyinthebrazilianamazonhivandriskofvivaxmalaria