Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm

BACKGROUND: Thoracic aortic aneurysm (TAA) is the permanent dilation of the thoracic aortic wall that predisposes patients to lethal events such as aortic dissection or rupture, for which effective medical therapy remains scarce. Human-relevant microphysiological models serve as a promising tool in...

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Detalles Bibliográficos
Autores principales: Ma, Wenrui, Zhang, Jingjing, Liu, Shaowen, Yan, Shiqiang, Xu, Kehua, Zhang, Yu Shrike, Abudupataer, Mieradilijiang, Ming, Yang, Zhu, Shichao, Xiang, Bitao, Zhou, Xiaonan, Luo, Shaman, Huang, Hui, Tang, Yuyi, Zhang, Shan, Xie, Zhuxin, Chen, Nan, Sun, Xiaoning, Li, Jun, Lai, Hao, Wang, Chunsheng, Zhu, Kai, Zhang, Weijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156889/
https://www.ncbi.nlm.nih.gov/pubmed/35636318
http://dx.doi.org/10.1016/j.ebiom.2022.104080

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