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Seed banks alter the molecular evolutionary dynamics of Bacillus subtilis

Fluctuations in the availability of resources constrain the growth and reproduction of individuals, which subsequently affects the evolution of their respective populations. Many organisms contend with such fluctuations by entering a reversible state of reduced metabolic activity, a phenomenon known...

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Autores principales: Shoemaker, William R, Polezhaeva, Evgeniya, Givens, Kenzie B, Lennon, Jay T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157070/
https://www.ncbi.nlm.nih.gov/pubmed/35511143
http://dx.doi.org/10.1093/genetics/iyac071
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author Shoemaker, William R
Polezhaeva, Evgeniya
Givens, Kenzie B
Lennon, Jay T
author_facet Shoemaker, William R
Polezhaeva, Evgeniya
Givens, Kenzie B
Lennon, Jay T
author_sort Shoemaker, William R
collection PubMed
description Fluctuations in the availability of resources constrain the growth and reproduction of individuals, which subsequently affects the evolution of their respective populations. Many organisms contend with such fluctuations by entering a reversible state of reduced metabolic activity, a phenomenon known as dormancy. This pool of dormant individuals (i.e. a seed bank) does not reproduce and is expected to act as an evolutionary buffer, though it is difficult to observe this effect directly over an extended evolutionary timescale. Through genetic manipulation, we analyze the molecular evolutionary dynamics of Bacillus subtilis populations in the presence and absence of a seed bank over 700 days. The ability of these bacteria to enter a dormant state increased the accumulation of genetic diversity over time and altered the trajectory of mutations, findings that were recapitulated using simulations based on a mathematical model of evolutionary dynamics. While the ability to form a seed bank did not alter the degree of negative selection, we found that it consistently altered the direction of molecular evolution across genes. Together, these results show that the ability to form a seed bank can affect the direction and rate of molecular evolution over an extended evolutionary timescale.
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spelling pubmed-91570702022-06-04 Seed banks alter the molecular evolutionary dynamics of Bacillus subtilis Shoemaker, William R Polezhaeva, Evgeniya Givens, Kenzie B Lennon, Jay T Genetics Investigation Fluctuations in the availability of resources constrain the growth and reproduction of individuals, which subsequently affects the evolution of their respective populations. Many organisms contend with such fluctuations by entering a reversible state of reduced metabolic activity, a phenomenon known as dormancy. This pool of dormant individuals (i.e. a seed bank) does not reproduce and is expected to act as an evolutionary buffer, though it is difficult to observe this effect directly over an extended evolutionary timescale. Through genetic manipulation, we analyze the molecular evolutionary dynamics of Bacillus subtilis populations in the presence and absence of a seed bank over 700 days. The ability of these bacteria to enter a dormant state increased the accumulation of genetic diversity over time and altered the trajectory of mutations, findings that were recapitulated using simulations based on a mathematical model of evolutionary dynamics. While the ability to form a seed bank did not alter the degree of negative selection, we found that it consistently altered the direction of molecular evolution across genes. Together, these results show that the ability to form a seed bank can affect the direction and rate of molecular evolution over an extended evolutionary timescale. Oxford University Press 2022-05-02 /pmc/articles/PMC9157070/ /pubmed/35511143 http://dx.doi.org/10.1093/genetics/iyac071 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Genetics Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Investigation
Shoemaker, William R
Polezhaeva, Evgeniya
Givens, Kenzie B
Lennon, Jay T
Seed banks alter the molecular evolutionary dynamics of Bacillus subtilis
title Seed banks alter the molecular evolutionary dynamics of Bacillus subtilis
title_full Seed banks alter the molecular evolutionary dynamics of Bacillus subtilis
title_fullStr Seed banks alter the molecular evolutionary dynamics of Bacillus subtilis
title_full_unstemmed Seed banks alter the molecular evolutionary dynamics of Bacillus subtilis
title_short Seed banks alter the molecular evolutionary dynamics of Bacillus subtilis
title_sort seed banks alter the molecular evolutionary dynamics of bacillus subtilis
topic Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157070/
https://www.ncbi.nlm.nih.gov/pubmed/35511143
http://dx.doi.org/10.1093/genetics/iyac071
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