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The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans

Non-human primates (NHP) are widely used for the pre-clinical assessment of antiretrovirals (ARVs) for HIV treatment and prevention. However, the utility of these models is questionable given the differences in ARV pharmacology between humans and macaques. Here, we report a model based on ex vivo AR...

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Detalles Bibliográficos
Autores principales:	Herrera, Carolina, Cottrell, Mackenzie L., Prybylski, John, Kashuba, Angela D.M., Veazey, Ronald S., García-Pérez, Javier, Olejniczak, Natalia, McCoy, Clare F., Ziprin, Paul, Richardson-Harman, Nicola, Alcami, José, Malcolm, Karl R., Shattock, Robin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157191/ https://www.ncbi.nlm.nih.gov/pubmed/35663021 http://dx.doi.org/10.1016/j.isci.2022.104409

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