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The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity
Intestinal environment disorder is a potential pathological mechanism of obesity. There is increasing evidence that disorders in the homeostasis of the intestinal environment can affect various metabolic organs, such as fat and liver, and lead to metabolic diseases. However, there are few therapeuti...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157426/ https://www.ncbi.nlm.nih.gov/pubmed/35662937 http://dx.doi.org/10.3389/fnut.2022.886902 |
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author | You, Huimin Tan, Yue Yu, Dawei Qiu, Shuting Bai, Yan He, Jincan Cao, Hua Che, Qishi Guo, Jiao Su, Zhengquan |
author_facet | You, Huimin Tan, Yue Yu, Dawei Qiu, Shuting Bai, Yan He, Jincan Cao, Hua Che, Qishi Guo, Jiao Su, Zhengquan |
author_sort | You, Huimin |
collection | PubMed |
description | Intestinal environment disorder is a potential pathological mechanism of obesity. There is increasing evidence that disorders in the homeostasis of the intestinal environment can affect various metabolic organs, such as fat and liver, and lead to metabolic diseases. However, there are few therapeutic approaches for obesity targeting the intestinal environment. In this review, on the one hand, we discuss how intestinal microbial metabolites SCFA regulate intestinal function to improve obesity and the possible mechanisms and pathways related to obesity-related pathological processes (depending on SCFA-related receptors such as GPCRs, MCT and SMCT, and through epigenetic processes). On the other hand, we discuss dietary management strategies to enrich SCFA-producing bacteria and target specific SCFA-producing bacteria and whether fecal bacteria transplantation therapy to restore the composition of the gut microbiota to regulate SCFA can help prevent or improve obesity. Finally, we believe that it will be of great significance to establish a working model of gut– SCFA– metabolic disease development in the future for the improvement this human health concern. |
format | Online Article Text |
id | pubmed-9157426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91574262022-06-02 The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity You, Huimin Tan, Yue Yu, Dawei Qiu, Shuting Bai, Yan He, Jincan Cao, Hua Che, Qishi Guo, Jiao Su, Zhengquan Front Nutr Nutrition Intestinal environment disorder is a potential pathological mechanism of obesity. There is increasing evidence that disorders in the homeostasis of the intestinal environment can affect various metabolic organs, such as fat and liver, and lead to metabolic diseases. However, there are few therapeutic approaches for obesity targeting the intestinal environment. In this review, on the one hand, we discuss how intestinal microbial metabolites SCFA regulate intestinal function to improve obesity and the possible mechanisms and pathways related to obesity-related pathological processes (depending on SCFA-related receptors such as GPCRs, MCT and SMCT, and through epigenetic processes). On the other hand, we discuss dietary management strategies to enrich SCFA-producing bacteria and target specific SCFA-producing bacteria and whether fecal bacteria transplantation therapy to restore the composition of the gut microbiota to regulate SCFA can help prevent or improve obesity. Finally, we believe that it will be of great significance to establish a working model of gut– SCFA– metabolic disease development in the future for the improvement this human health concern. Frontiers Media S.A. 2022-05-17 /pmc/articles/PMC9157426/ /pubmed/35662937 http://dx.doi.org/10.3389/fnut.2022.886902 Text en Copyright © 2022 You, Tan, Yu, Qiu, Bai, He, Cao, Che, Guo and Su. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition You, Huimin Tan, Yue Yu, Dawei Qiu, Shuting Bai, Yan He, Jincan Cao, Hua Che, Qishi Guo, Jiao Su, Zhengquan The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity |
title | The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity |
title_full | The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity |
title_fullStr | The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity |
title_full_unstemmed | The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity |
title_short | The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity |
title_sort | therapeutic effect of scfa-mediated regulation of the intestinal environment on obesity |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157426/ https://www.ncbi.nlm.nih.gov/pubmed/35662937 http://dx.doi.org/10.3389/fnut.2022.886902 |
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