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Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child

The association of paracoccidioidomycosis (PCM) and tuberculosis (TB) produces an uncommon hyperinflammatory syndrome, causing multiorgan dysfunction. TB associated PCM is a rare condition, but it is fatal if not treated. Herein, we present a immunocompetent child who is admitted for fever and painf...

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Autores principales: Montalvo, Raúl, Díaz, Anibal, Montalvo, Josdan, Pomazongo, Manuel, Montalvo, Miguel, Tunque, Edison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157441/
https://www.ncbi.nlm.nih.gov/pubmed/35663608
http://dx.doi.org/10.1016/j.idcr.2022.e01507
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author Montalvo, Raúl
Díaz, Anibal
Montalvo, Josdan
Pomazongo, Manuel
Montalvo, Miguel
Tunque, Edison
author_facet Montalvo, Raúl
Díaz, Anibal
Montalvo, Josdan
Pomazongo, Manuel
Montalvo, Miguel
Tunque, Edison
author_sort Montalvo, Raúl
collection PubMed
description The association of paracoccidioidomycosis (PCM) and tuberculosis (TB) produces an uncommon hyperinflammatory syndrome, causing multiorgan dysfunction. TB associated PCM is a rare condition, but it is fatal if not treated. Herein, we present a immunocompetent child who is admitted for fever and painful lymphadenopathy, with evidence of acid-alcohol-resistant bacillus (AARB) in cervical lymph node biopsy, antituberculous treatment was started with partial clinical improvement and is given discharge from hospital. At 3 weeks, he was readmitted by fever, weight loss, dyspnea and a greater number of adenopathies, in the new biopsy multiple yeasts were found compatible with PCM, our patient responded well to the combination of antituberculosis therapy(ATT), corticosteroid, and amphotericin B deoxycholate, presenting clinical improvement and subsequently continued with itraconazole.
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spelling pubmed-91574412022-06-02 Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child Montalvo, Raúl Díaz, Anibal Montalvo, Josdan Pomazongo, Manuel Montalvo, Miguel Tunque, Edison IDCases Case Report The association of paracoccidioidomycosis (PCM) and tuberculosis (TB) produces an uncommon hyperinflammatory syndrome, causing multiorgan dysfunction. TB associated PCM is a rare condition, but it is fatal if not treated. Herein, we present a immunocompetent child who is admitted for fever and painful lymphadenopathy, with evidence of acid-alcohol-resistant bacillus (AARB) in cervical lymph node biopsy, antituberculous treatment was started with partial clinical improvement and is given discharge from hospital. At 3 weeks, he was readmitted by fever, weight loss, dyspnea and a greater number of adenopathies, in the new biopsy multiple yeasts were found compatible with PCM, our patient responded well to the combination of antituberculosis therapy(ATT), corticosteroid, and amphotericin B deoxycholate, presenting clinical improvement and subsequently continued with itraconazole. Elsevier 2022-05-20 /pmc/articles/PMC9157441/ /pubmed/35663608 http://dx.doi.org/10.1016/j.idcr.2022.e01507 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Montalvo, Raúl
Díaz, Anibal
Montalvo, Josdan
Pomazongo, Manuel
Montalvo, Miguel
Tunque, Edison
Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child
title Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child
title_full Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child
title_fullStr Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child
title_full_unstemmed Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child
title_short Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child
title_sort disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157441/
https://www.ncbi.nlm.nih.gov/pubmed/35663608
http://dx.doi.org/10.1016/j.idcr.2022.e01507
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