FcRn Antagonism Leads to a Decrease of Desmoglein-Specific B Cells: Secondary Analysis of a Phase 2 Study of Efgartigimod in Pemphigus Vulgaris and Pemphigus Foliaceus

BACKGROUND: Immunoglobulin G (IgG) levels are maintained by the IgG-recycling neonatal Fc-receptor (FcRn). Pemphigus vulgaris and pemphigus foliaceus are debilitating autoimmune disorders triggered by IgG autoantibodies against mucosal and epidermal desmogleins. Recently, a phase 2 clinical trial (N...

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Detalles Bibliográficos
Autores principales: Maho-Vaillant, Maud, Sips, Magdalena, Golinski, Marie-Laure, Vidarsson, Gestur, Goebeler, Matthias, Stoevesandt, Johanna, Bata-Csörgő, Zsuzsanna, Balbino, Bianca, Verheesen, Peter, Joly, Pascal, Hertl, Michael, Calbo, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157593/
https://www.ncbi.nlm.nih.gov/pubmed/35663943
http://dx.doi.org/10.3389/fimmu.2022.863095

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