Inhibition of glutathione metabolism can limit the development of pancreatic cancer

Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chemotherapy resistance. Nevertheless, buthionine-sulfoximin...

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Autores principales: Cai, Pei-Yuan, Ma, Mei-Lin, Zhang, Yang-Fen, Zhou, Zi-Xuan, Wang, Yan, He, Lian-Ping, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157600/
https://www.ncbi.nlm.nih.gov/pubmed/35722199
http://dx.doi.org/10.4252/wjsc.v14.i5.362
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author Cai, Pei-Yuan
Ma, Mei-Lin
Zhang, Yang-Fen
Zhou, Zi-Xuan
Wang, Yan
He, Lian-Ping
Wang, Wei
author_facet Cai, Pei-Yuan
Ma, Mei-Lin
Zhang, Yang-Fen
Zhou, Zi-Xuan
Wang, Yan
He, Lian-Ping
Wang, Wei
author_sort Cai, Pei-Yuan
collection PubMed
description Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chemotherapy resistance. Nevertheless, buthionine-sulfoximine also decreases the content of glutathione in normal cells, disrupts the balance between reactive oxygen species and glutathione, and eventually induces cell apoptosis. Pancreatic cancer is usually diagnosed at an advanced stage and has a poor prognosis. Consequently, the use of biomarkers to screen high-risk patients can be an effective method.
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spelling pubmed-91576002022-06-17 Inhibition of glutathione metabolism can limit the development of pancreatic cancer Cai, Pei-Yuan Ma, Mei-Lin Zhang, Yang-Fen Zhou, Zi-Xuan Wang, Yan He, Lian-Ping Wang, Wei World J Stem Cells Letter to the Editor Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chemotherapy resistance. Nevertheless, buthionine-sulfoximine also decreases the content of glutathione in normal cells, disrupts the balance between reactive oxygen species and glutathione, and eventually induces cell apoptosis. Pancreatic cancer is usually diagnosed at an advanced stage and has a poor prognosis. Consequently, the use of biomarkers to screen high-risk patients can be an effective method. Baishideng Publishing Group Inc 2022-05-26 2022-05-26 /pmc/articles/PMC9157600/ /pubmed/35722199 http://dx.doi.org/10.4252/wjsc.v14.i5.362 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Letter to the Editor
Cai, Pei-Yuan
Ma, Mei-Lin
Zhang, Yang-Fen
Zhou, Zi-Xuan
Wang, Yan
He, Lian-Ping
Wang, Wei
Inhibition of glutathione metabolism can limit the development of pancreatic cancer
title Inhibition of glutathione metabolism can limit the development of pancreatic cancer
title_full Inhibition of glutathione metabolism can limit the development of pancreatic cancer
title_fullStr Inhibition of glutathione metabolism can limit the development of pancreatic cancer
title_full_unstemmed Inhibition of glutathione metabolism can limit the development of pancreatic cancer
title_short Inhibition of glutathione metabolism can limit the development of pancreatic cancer
title_sort inhibition of glutathione metabolism can limit the development of pancreatic cancer
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157600/
https://www.ncbi.nlm.nih.gov/pubmed/35722199
http://dx.doi.org/10.4252/wjsc.v14.i5.362
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