Cargando…

Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer

BACKGROUND: Colorectal cancer (CRC) is one of the three major cancers in the world and is the cancer with the most liver metastasis. The present study aimed to investigate the role of metallothionein 2A (MT2A) in the modulation of CRC cell proliferation and liver metastasis, as well as its molecular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xi, Quan, Jun, Shen, Zhaolong, Zhang, Zequn, Chen, Zhijian, Li, Liang, Li, Xiaorong, Hu, Gui, Deng, Xiaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158144/ https://www.ncbi.nlm.nih.gov/pubmed/35642057 http://dx.doi.org/10.1186/s12935-022-02623-w

Ejemplares similares

The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis
por: Zinatizadeh, Mohammad Reza, et al.
Publicado: (2019)

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
por: Avruch, J, et al.
Publicado: (2011)

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner
por: García-Gutiérrez, Lucía, et al.
Publicado: (2022)

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
por: Meng, Zhipeng, et al.
Publicado: (2015)

Mst1 and Mst2 kinases: regulations and diseases
por: Qin, Funiu, et al.
Publicado: (2013)

Functional Role of Mst1/Mst2 in Embryonic Stem Cell Differentiation
por: Li, Peng, et al.
Publicado: (2013)

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes
por: Mou, Fan, et al.
Publicado: (2012)

Effects of Quinacrine on Expression of Hippo signaling Pathway Components (LATS1, LATS2, and YAP) in Human Breast Cancer Stem Cells
por: Darbankhales, Soroush, et al.
Publicado: (2020)

Mst1 and Mst2 Are Essential Regulators of Trophoblast Differentiation and Placenta Morphogenesis
por: Du, Xingrong, et al.
Publicado: (2014)

Effect of Inactivation of Mst1 and Mst2 in the Mouse Adrenal Cortex
por: Abou Nader, Nour, et al.
Publicado: (2022)

The TGF(β)→TAK1→LATS→YAP1 Pathway Regulates the Spatiotemporal Dynamics of YAP1
por: Kim, Min-Kyu, et al.
Publicado: (2023)

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade
por: Lodge, Emily J, et al.
Publicado: (2019)

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling
por: Ni, Lisheng, et al.
Publicado: (2015)

Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis
por: Tian, Hui, et al.
Publicado: (2021)

The novel long non-coding RNA LATS2-AS1-001 inhibits gastric cancer progression by regulating the LATS2/YAP1 signaling pathway via binding to EZH2
por: Sun, Dan, et al.
Publicado: (2020)

Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose
por: Su, Dongmei, et al.
Publicado: (2021)

β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity
por: Kim, Minsuh, et al.
Publicado: (2022)

The kinases Mst1 and Mst2 positively regulate phagocyte ROS induction and bactericidal activity
por: Geng, Jing, et al.
Publicado: (2015)

NR1B2 suppress kidney renal clear cell carcinoma (KIRC) progression by regulation of LATS 1/2-YAP signaling
por: Yin, Lei, et al.
Publicado: (2019)

Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors
por: Kantipudi, Satish, et al.
Publicado: (2021)

S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway
por: Tao, Yi-Ping, et al.
Publicado: (2023)

The Sp1/FOXC1/HOTTIP/LATS2/YAP/β‐catenin cascade promotes malignant and metastatic progression of osteosarcoma
por: Liu, Ke, et al.
Publicado: (2020)

Retraction Note: The novel long non-coding RNA LATS2-AS1-001 inhibits gastric cancer progression by regulating the LATS2/YAP1 signaling pathway via binding to EZH2
por: Sun, Dan, et al.
Publicado: (2022)

NRP1 transduces mechanical stress inhibition via LATS1/YAP in hypertrophic scars
por: Li, Mengzhi, et al.
Publicado: (2023)

OR24-4 Homeostatic and Tumourigenic Activity of SOX2+ Pituitary Stem Cells is Controlled by the LATS/YAP/TAZ Cascade
por: Lodge, Emily, et al.
Publicado: (2019)

RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer
por: Pan, Yi, et al.
Publicado: (2018)

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis
por: Turunen, S. Pauliina, et al.
Publicado: (2019)

Calotropin activates YAP through downregulation of LATS1 in colorectal cancer cells
por: Zhou, Limin, et al.
Publicado: (2019)

The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma.
por: Lu, Dong-Dong, et al.
Publicado: (2003)

WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice
por: Park, Jaeoh, et al.
Publicado: (2020)

Pharmacological Activation of YAP/TAZ by Targeting LATS1/2 Enhances Periodontal Tissue Regeneration in a Murine Model
por: Sato, Akiko, et al.
Publicado: (2023)

Functional characterization of a type 2 metallothionein gene, SsMT2, from alkaline-tolerant Suaeda salsa
por: Jin, Shumei, et al.
Publicado: (2017)

Platycodin D confers oxaliplatin Resistance in Colorectal Cancer by activating the LATS2/YAP1 axis of the hippo signaling pathway
por: Wang, Chien-Hao, et al.
Publicado: (2023)

Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation
por: Najafi, Maryam, et al.
Publicado: (2016)

17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway
por: Ye, Xiang-Yun, et al.
Publicado: (2015)

Towards an understanding of the roles of visual areas MT and MST in computing speed
por: Meso, Andrew Isaac, et al.
Publicado: (2014)

Association analysis between SNPs in LATS1 and LATS2 and non-cardia gastric cancer
por: Ma, Li-cong, et al.
Publicado: (2020)

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function
por: Tang, Fengyuan, et al.
Publicado: (2019)

Mst1 inhibits autophagy by promoting Beclin1-Bcl-2 interaction
por: Maejima, Yasuhiro, et al.
Publicado: (2013)

Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors
por: Barollo, Susi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_uttu5btaodco4v691t7umiqcpf