Cargando…

Organocatalytic enantioselective S(N)1-type dehydrative nucleophilic substitution: access to bis(indolyl)methanes bearing quaternary carbon stereocenters

A highly general and straightforward approach to access chiral bis(indolyl)methanes (BIMs) bearing quaternary stereocenters has been realized via enantioconvergent dehydrative nucleophilic substitution. A broad range of 3,3′-, 3,2′- and 3,1′-BIMs were obtained under mild conditions with excellent ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Wen-Run, Su, Qiong, Deng, Xiao-Yi, Liu, Jia-Sheng, Zhong, Tao, Meng, Shan-Shui, Yi, Ji-Tao, Weng, Jiang, Lu, Gui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158264/ https://www.ncbi.nlm.nih.gov/pubmed/35733509 http://dx.doi.org/10.1039/d1sc05174a

Ejemplares similares

Enantioselective construction of triaryl-substituted all-carbon quaternary stereocenters via organocatalytic arylation of oxindoles with azonaphthalenes
por: Chen, Pengquan, et al.
Publicado: (2023)

Stereoinvertive Nucleophilic Substitution at Quaternary Carbon Stereocenters of Cyclopropyl Ketones and Ethers
por: Chen, Xu, et al.
Publicado: (2022)

Enantioselective Construction of Tertiary Fluoride Stereocenters by Organocatalytic Fluorocyclization
por: Wang, Qiang, et al.
Publicado: (2020)

Enantioselective Construction of Remote Quaternary Stereocenters
por: Mei, Tian-Sheng, et al.
Publicado: (2014)

Stereoselective Construction of Tertiary Homoallyl Alcohols and Ethers by Nucleophilic Substitution at Quaternary Carbon Stereocenters
por: Chen, Xu, et al.
Publicado: (2022)

Catalytic enantioselective construction of vicinal quaternary carbon stereocenters
por: Zhou, Feng, et al.
Publicado: (2020)

Organocatalytic asymmetric formal oxidative coupling for the construction of all-aryl quaternary stereocenters
por: Li, Zhiyang, et al.
Publicado: (2021)

Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter
por: Zhu, Xiao-Yu, et al.
Publicado: (2018)

Catalytic Enantioselective Entry to Triflones Featuring a Quaternary Stereocenter
por: Franco, Francesca, et al.
Publicado: (2022)

Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
por: Zhang, Qing, et al.
Publicado: (2019)

Enantioselective [2 + 2] cycloaddition of N-allenamides with cyclic N-sulfonylketimines: access to polysubstituted azetidines bearing quaternary stereocenters
por: Liu, Ren-Rong, et al.
Publicado: (2017)

Cross-dehydrogenative coupling enables enantioselective access to CF(3)-substituted all-carbon quaternary stereocenters
por: Pan, Xiaoguang, et al.
Publicado: (2020)

Forging Fluorine‐Containing Quaternary Stereocenters by a Light‐Driven Organocatalytic Aldol Desymmetrization Process
por: Cuadros, Sara, et al.
Publicado: (2017)

Asymmetric Synthesis of Spirocyclopentane Oxindoles Containing Four Consecutive Stereocenters and Quaternary α-Nitro Esters via Organocatalytic Enantioselective Michael–Michael Cascade Reactions
por: Chaudhari, Prakash D., et al.
Publicado: (2019)

Stereospecific Construction of Quaternary Carbon Stereocenters from Quaternary Carbon Stereocenters
por: Patel, Kaushalendra, et al.
Publicado: (2022)

Biocatalytic Conversion of Cyclic Ketones Bearing α‐Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium‐Sized Carbocycles
por: Morrill, Charlotte, et al.
Publicado: (2018)

Highly Enantioselective Iridium(I)‐Catalyzed Hydrocarbonation of Alkenes: A Versatile Approach to Heterocyclic Systems Bearing Quaternary Stereocenters
por: Arribas, Andrés, et al.
Publicado: (2021)

Enantioselective Synthesis of Acyclic Orthogonally Functionalized Compounds Bearing a Quaternary Stereocenter Using Chiral Ammonium Salt Catalysis
por: Röser, Katharina, et al.
Publicado: (2021)

Enantioselective Narasaka–Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters
por: Race, Nicholas J., et al.
Publicado: (2017)

Stereospecific nucleophilic substitution at tertiary and quaternary stereocentres
por: Lanke, Veeranjaneyulu, et al.
Publicado: (2020)

Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
por: Wang, Jiawen, et al.
Publicado: (2021)

Enantioselective Synthesis of Aza-Flavanones with an All-Carbon Quaternary Stereocenter via NHC-Catalyzed Intramolecular Annulation
por: Barańska, Izabela, et al.
Publicado: (2023)

Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
por: Zheng, Haifeng, et al.
Publicado: (2018)

Construction of polycyclic structures with vicinal all-carbon quaternary stereocenters via an enantioselective photoenolization/Diels–Alder reaction
por: Hou, Min, et al.
Publicado: (2021)

Enantioselective [3+2]-cycloaddition of 2,3-disubstituted cyclobutenones: vicinal quaternary stereocenters construction and skeletal functionalization
por: Lu, Licheng, et al.
Publicado: (2023)

Stereocontrolled access to δ-lactone-fused-γ-lactams bearing angular benzylic quaternary stereocenters
por: Beng, Timothy K., et al.
Publicado: (2022)

Organocatalytic asymmetric azidation of sulfoxonium ylides: mild synthesis of enantioenriched α-azido ketones bearing a labile tertiary stereocenter
por: Guo, Wengang, et al.
Publicado: (2022)

Stereoselective amine-thiourea-catalysed sulfa-Michael/nitroaldol cascade approach to 3,4,5-substituted tetrahydrothiophenes bearing a quaternary stereocenter
por: Meninno, Sara, et al.
Publicado: (2016)

Friedel–Crafts Reaction of Acylsilanes: Highly Chemoselective Synthesis of 1-Hydroxy-bis(indolyl)methanes and 1-Silyl-bis(indolyl)methanes Derivatives
por: Li, Qi, et al.
Publicado: (2023)

Diastereodivergent Synthesis of Cyclopentyl Boronic Esters Bearing Contiguous Fully Substituted Stereocenters
por: Fairchild, Molly E., et al.
Publicado: (2022)

Catalytic enantioselective synthesis of fluoromethylated stereocenters by asymmetric hydrogenation
por: Yang, Jianping, et al.
Publicado: (2022)

Nickel-catalyzed enantioselective α-heteroarylation of ketones via C–F bond activation to construct all-carbon quaternary stereocenters
por: Gu, Xiaodong, et al.
Publicado: (2022)

Synthesis of bis(indolyl)methanes Catalyzed by Triethylborane
por: Merinos, J. Pablo García, et al.
Publicado: (2015)

Asymmetric synthesis of functionalized cyclohexanes bearing five stereocenters via a one-pot organocatalytic Michael–Michael–1,2-addition sequence
por: Chauhan, Pankaj, et al.
Publicado: (2014)

Quaternary Stereocenters via an Enantioconvergent Catalytic S(N)1 Reaction
por: Wendlandt, Alison E., et al.
Publicado: (2018)

Doubly stereoconvergent construction of vicinal all-carbon quaternary and tertiary stereocenters by Cu/Mg-catalyzed propargylic substitution
por: Pu, Xiang, et al.
Publicado: (2022)

Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters
por: Woźniak, Łukasz, et al.
Publicado: (2015)

Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water
por: Fu, Yajie, et al.
Publicado: (2020)

Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters
por: Trost, B. M., et al.
Publicado: (2018)

Accessing chiral sulfones bearing quaternary carbon stereocenters via photoinduced radical sulfur dioxide insertion and Truce–Smiles rearrangement
por: Huang, Jiapian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pqpgd18n5eqqqg18c0mnghu30t