N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer’s pathophysiology

BACKGROUND: The molecular heterogeneity of Alzheimer’s amyloid-β (Aβ) deposits extends well beyond the classic Aβ1-40/Aβ1-42 dichotomy, substantially expanded by multiple post-translational modifications that increase the proteome diversity. Numerous truncated fragments consistently populate the bra...

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Detalles Bibliográficos
Autores principales: Rostagno, Agueda, Cabrera, Erwin, Lashley, Tammaryn, Ghiso, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158284/
https://www.ncbi.nlm.nih.gov/pubmed/35641972
http://dx.doi.org/10.1186/s40035-022-00303-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158284/
https://www.ncbi.nlm.nih.gov/pubmed/35641972
http://dx.doi.org/10.1186/s40035-022-00303-3

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