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BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication
BACKGROUND: Bovine Viral Diarrhoea Virus (BVDV) infection remains endemic in many countries worldwide. Ireland, in common with several other European counties, commenced an BVDV eradication programme in the last decade, Managing eradication programmes requires careful monitoring of diseases prevalen...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158290/ https://www.ncbi.nlm.nih.gov/pubmed/35650625 http://dx.doi.org/10.1186/s12917-022-03318-0 |
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author | Barrett, Damien Clarke, AnneMarie O’Keeffe, Kate Kellegher, Padraig Comerford, John Lane, Elizabeth Byrne, Andrew W. |
author_facet | Barrett, Damien Clarke, AnneMarie O’Keeffe, Kate Kellegher, Padraig Comerford, John Lane, Elizabeth Byrne, Andrew W. |
author_sort | Barrett, Damien |
collection | PubMed |
description | BACKGROUND: Bovine Viral Diarrhoea Virus (BVDV) infection remains endemic in many countries worldwide. Ireland, in common with several other European counties, commenced an BVDV eradication programme in the last decade, Managing eradication programmes requires careful monitoring of diseases prevalence and understanding factors associated with disease exposure to ensure eradication programmes remain evidence based and tailored to the evolving epidemiological situation. METHODS: In this study, we explore the seroprevalence of BVDV exposure over a four-year period (2017 to 2020) in Ireland from a cohort of animals (n = 6,449) under 30 months of age sampled at slaughter, who were born subsequent to the commencement of a compulsory national eradication programme. Temporal trends and risk factor analysis were undertaken using multilevel logit regression models. RESULTS: There was a declining temporal trend in seroprevalence over the sample years of the study, and risk varied at both county- and herd-levels. The unadjusted marginal animal-level seroprevalence reduced from 9.1% in 2017 (95%; CI: 7.2—10.9) to 3.9% in 2020 (95%; CI: 3.2—4.6). The final model suggested that seropositivity in study cattle was strongly related with the presence of a PI animal in the herd during the year of the animal’s birth, and to a lesser extent the status of the herd from which the animal was slaughtered. The risk of seroconversion increased significantly with increasing size of the herd of slaughter, in females relative to males, and in dairy relative to suckler herds. CONCLUSIONS: This study has shown that the BVDV serostatus of cattle at slaughter is correlated to the BVD infection history of the herd into which the animal was born and the herd from which it was slaughtered. Herd location, increased herd size and dairy production were associated with increased probability of serconversion. These findings will be used to inform the targeting of surveillance strategies once BVDV freedom has been achieved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03318-0. |
format | Online Article Text |
id | pubmed-9158290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91582902022-06-02 BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication Barrett, Damien Clarke, AnneMarie O’Keeffe, Kate Kellegher, Padraig Comerford, John Lane, Elizabeth Byrne, Andrew W. BMC Vet Res Research BACKGROUND: Bovine Viral Diarrhoea Virus (BVDV) infection remains endemic in many countries worldwide. Ireland, in common with several other European counties, commenced an BVDV eradication programme in the last decade, Managing eradication programmes requires careful monitoring of diseases prevalence and understanding factors associated with disease exposure to ensure eradication programmes remain evidence based and tailored to the evolving epidemiological situation. METHODS: In this study, we explore the seroprevalence of BVDV exposure over a four-year period (2017 to 2020) in Ireland from a cohort of animals (n = 6,449) under 30 months of age sampled at slaughter, who were born subsequent to the commencement of a compulsory national eradication programme. Temporal trends and risk factor analysis were undertaken using multilevel logit regression models. RESULTS: There was a declining temporal trend in seroprevalence over the sample years of the study, and risk varied at both county- and herd-levels. The unadjusted marginal animal-level seroprevalence reduced from 9.1% in 2017 (95%; CI: 7.2—10.9) to 3.9% in 2020 (95%; CI: 3.2—4.6). The final model suggested that seropositivity in study cattle was strongly related with the presence of a PI animal in the herd during the year of the animal’s birth, and to a lesser extent the status of the herd from which the animal was slaughtered. The risk of seroconversion increased significantly with increasing size of the herd of slaughter, in females relative to males, and in dairy relative to suckler herds. CONCLUSIONS: This study has shown that the BVDV serostatus of cattle at slaughter is correlated to the BVD infection history of the herd into which the animal was born and the herd from which it was slaughtered. Herd location, increased herd size and dairy production were associated with increased probability of serconversion. These findings will be used to inform the targeting of surveillance strategies once BVDV freedom has been achieved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03318-0. BioMed Central 2022-06-01 /pmc/articles/PMC9158290/ /pubmed/35650625 http://dx.doi.org/10.1186/s12917-022-03318-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Barrett, Damien Clarke, AnneMarie O’Keeffe, Kate Kellegher, Padraig Comerford, John Lane, Elizabeth Byrne, Andrew W. BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication |
title | BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication |
title_full | BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication |
title_fullStr | BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication |
title_full_unstemmed | BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication |
title_short | BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication |
title_sort | bvd seroprevalence in the irish cattle population as the national bvd programme progresses toward eradication |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158290/ https://www.ncbi.nlm.nih.gov/pubmed/35650625 http://dx.doi.org/10.1186/s12917-022-03318-0 |
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