A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector

BACKGROUND: Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile. BSEP expression is regulated by BA levels through activation of farnesoid X receptor transcription factor, which binds to the inverted repeat (IR-1)...

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Detalles Bibliográficos
Autores principales: Martínez-García, Javier, Molina, Manuela, Odriozola, Leticia, Molina, Angie, González-Aseguinolaza, Gloria, Weber, Nicholas D., Smerdou, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158313/
https://www.ncbi.nlm.nih.gov/pubmed/35641984
http://dx.doi.org/10.1186/s13578-022-00803-9

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