Cargando…
Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran
OBJECTIVE: We sought to evaluate the neurodevelopmental outcomes at 12 months of age among infants with twin-to-twin transfusion syndrome (TTTS) undergoing fetoscopic laser photocoagulation (FLP). MATERIALS AND METHODS: In this prospective longitudinal study, neurodevelopmental assessment was perfor...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158318/ https://www.ncbi.nlm.nih.gov/pubmed/35650560 http://dx.doi.org/10.1186/s12884-022-04793-x |
_version_ | 1784718810354286592 |
---|---|
author | Mesbah, Nazila Marsousi, Vajiheh Eslamian, Laleh Montazerlotfelahi, Hadi Shamshirsaz, Alireza A. Hessami, Kamran Jamal, Ashraf Noorzadeh, Maryam Naemi, Mahsa Ghaemi, Marjan |
author_facet | Mesbah, Nazila Marsousi, Vajiheh Eslamian, Laleh Montazerlotfelahi, Hadi Shamshirsaz, Alireza A. Hessami, Kamran Jamal, Ashraf Noorzadeh, Maryam Naemi, Mahsa Ghaemi, Marjan |
author_sort | Mesbah, Nazila |
collection | PubMed |
description | OBJECTIVE: We sought to evaluate the neurodevelopmental outcomes at 12 months of age among infants with twin-to-twin transfusion syndrome (TTTS) undergoing fetoscopic laser photocoagulation (FLP). MATERIALS AND METHODS: In this prospective longitudinal study, neurodevelopmental assessment was performed among the infants at the corrected age of 12 months, who were diagnosed with TTTS and treated by FLP. The Ages and Stages Questionnaire (ASQ) was filled out by parents. In the next step in infants with abnormal ASQ, motor and cognitive developments were evaluated by Bayley’s infant and toddler development scoring system (Bayley 3-Third edition). RESULTS: In 39 FLP procedures the rate of live birth of at least one twin was 73.8%. Four neonatal deaths were recorded, three of which were due to prematurity and one was due to heart anomaly. The ASQ was normal in 89.7% (35/39) of the infants (group I), 5.1% (2/39) had minor neurodevelopmental impairment (NDI) (group II), and 5.1% (2/39) had major NDI (group III). The 4 infants with abnormal ASQ had Bayley examination which showed two with mild to moderate cerebral palsy and two had delayed verbal skills and autistic spectrum disorder. No significant difference was noted between survivors with and without NDI with respect to donor or recipient status, birth weight, gestational age at birth, Quintero stage of TTTS. In addition, the relationship between gestational age at the time of undergoing FLC and NDI was not significant. CONCLUSION: In our population, minor and major neurodevelopmental impairment were seen in 10.2% of the infants. This information is useful for counseling our couples in this population prior the procedure. |
format | Online Article Text |
id | pubmed-9158318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91583182022-06-02 Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran Mesbah, Nazila Marsousi, Vajiheh Eslamian, Laleh Montazerlotfelahi, Hadi Shamshirsaz, Alireza A. Hessami, Kamran Jamal, Ashraf Noorzadeh, Maryam Naemi, Mahsa Ghaemi, Marjan BMC Pregnancy Childbirth Research OBJECTIVE: We sought to evaluate the neurodevelopmental outcomes at 12 months of age among infants with twin-to-twin transfusion syndrome (TTTS) undergoing fetoscopic laser photocoagulation (FLP). MATERIALS AND METHODS: In this prospective longitudinal study, neurodevelopmental assessment was performed among the infants at the corrected age of 12 months, who were diagnosed with TTTS and treated by FLP. The Ages and Stages Questionnaire (ASQ) was filled out by parents. In the next step in infants with abnormal ASQ, motor and cognitive developments were evaluated by Bayley’s infant and toddler development scoring system (Bayley 3-Third edition). RESULTS: In 39 FLP procedures the rate of live birth of at least one twin was 73.8%. Four neonatal deaths were recorded, three of which were due to prematurity and one was due to heart anomaly. The ASQ was normal in 89.7% (35/39) of the infants (group I), 5.1% (2/39) had minor neurodevelopmental impairment (NDI) (group II), and 5.1% (2/39) had major NDI (group III). The 4 infants with abnormal ASQ had Bayley examination which showed two with mild to moderate cerebral palsy and two had delayed verbal skills and autistic spectrum disorder. No significant difference was noted between survivors with and without NDI with respect to donor or recipient status, birth weight, gestational age at birth, Quintero stage of TTTS. In addition, the relationship between gestational age at the time of undergoing FLC and NDI was not significant. CONCLUSION: In our population, minor and major neurodevelopmental impairment were seen in 10.2% of the infants. This information is useful for counseling our couples in this population prior the procedure. BioMed Central 2022-06-01 /pmc/articles/PMC9158318/ /pubmed/35650560 http://dx.doi.org/10.1186/s12884-022-04793-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mesbah, Nazila Marsousi, Vajiheh Eslamian, Laleh Montazerlotfelahi, Hadi Shamshirsaz, Alireza A. Hessami, Kamran Jamal, Ashraf Noorzadeh, Maryam Naemi, Mahsa Ghaemi, Marjan Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran |
title | Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran |
title_full | Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran |
title_fullStr | Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran |
title_full_unstemmed | Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran |
title_short | Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran |
title_sort | infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from iran |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158318/ https://www.ncbi.nlm.nih.gov/pubmed/35650560 http://dx.doi.org/10.1186/s12884-022-04793-x |
work_keys_str_mv | AT mesbahnazila infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT marsousivajiheh infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT eslamianlaleh infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT montazerlotfelahihadi infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT shamshirsazalirezaa infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT hessamikamran infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT jamalashraf infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT noorzadehmaryam infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT naemimahsa infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran AT ghaemimarjan infantileneurodevelopmentaloutcomeafterfetoscopiclaserphotocoagulationfortwintotwintransfusionsyndromethefirstprospectiveexperiencefromiran |