Genetic associations with healthy ageing among Chinese adults

The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6...

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Detalles Bibliográficos
Autores principales: Chang, Xuling, Zhou, Yan-Feng, Wang, Ling, Liu, Jianjun, Yuan, Jian-Min, Khor, Chiea-Chuen, Heng, Chew-Kiat, Pan, An, Koh, Woon-Puay, Dorajoo, Rajkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158790/
https://www.ncbi.nlm.nih.gov/pubmed/35927272
http://dx.doi.org/10.1038/s41514-022-00086-x
Descripción
Sumario:The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified (P(Meta) < 2.59 × 10(−8)) to be associated with healthy aging, including the LRP1B locus previously associated in long-lived individuals without cognitive decline. Our study sheds additional insights on the genetic basis of healthy ageing.

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