Genetic associations with healthy ageing among Chinese adults

The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6...

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Autores principales: Chang, Xuling, Zhou, Yan-Feng, Wang, Ling, Liu, Jianjun, Yuan, Jian-Min, Khor, Chiea-Chuen, Heng, Chew-Kiat, Pan, An, Koh, Woon-Puay, Dorajoo, Rajkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158790/
https://www.ncbi.nlm.nih.gov/pubmed/35927272
http://dx.doi.org/10.1038/s41514-022-00086-x
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author Chang, Xuling
Zhou, Yan-Feng
Wang, Ling
Liu, Jianjun
Yuan, Jian-Min
Khor, Chiea-Chuen
Heng, Chew-Kiat
Pan, An
Koh, Woon-Puay
Dorajoo, Rajkumar
author_facet Chang, Xuling
Zhou, Yan-Feng
Wang, Ling
Liu, Jianjun
Yuan, Jian-Min
Khor, Chiea-Chuen
Heng, Chew-Kiat
Pan, An
Koh, Woon-Puay
Dorajoo, Rajkumar
author_sort Chang, Xuling
collection PubMed
description The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified (P(Meta) < 2.59 × 10(−8)) to be associated with healthy aging, including the LRP1B locus previously associated in long-lived individuals without cognitive decline. Our study sheds additional insights on the genetic basis of healthy ageing.
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spelling pubmed-91587902022-06-07 Genetic associations with healthy ageing among Chinese adults Chang, Xuling Zhou, Yan-Feng Wang, Ling Liu, Jianjun Yuan, Jian-Min Khor, Chiea-Chuen Heng, Chew-Kiat Pan, An Koh, Woon-Puay Dorajoo, Rajkumar NPJ Aging Brief Communication The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified (P(Meta) < 2.59 × 10(−8)) to be associated with healthy aging, including the LRP1B locus previously associated in long-lived individuals without cognitive decline. Our study sheds additional insights on the genetic basis of healthy ageing. Nature Publishing Group UK 2022-05-02 /pmc/articles/PMC9158790/ /pubmed/35927272 http://dx.doi.org/10.1038/s41514-022-00086-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Chang, Xuling
Zhou, Yan-Feng
Wang, Ling
Liu, Jianjun
Yuan, Jian-Min
Khor, Chiea-Chuen
Heng, Chew-Kiat
Pan, An
Koh, Woon-Puay
Dorajoo, Rajkumar
Genetic associations with healthy ageing among Chinese adults
title Genetic associations with healthy ageing among Chinese adults
title_full Genetic associations with healthy ageing among Chinese adults
title_fullStr Genetic associations with healthy ageing among Chinese adults
title_full_unstemmed Genetic associations with healthy ageing among Chinese adults
title_short Genetic associations with healthy ageing among Chinese adults
title_sort genetic associations with healthy ageing among chinese adults
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158790/
https://www.ncbi.nlm.nih.gov/pubmed/35927272
http://dx.doi.org/10.1038/s41514-022-00086-x
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