Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop N-glycan modulators as anticancer agents

Modulation of N-glycosylation using human Golgi α-mannosidase II (α-hGMII) inhibitors is a potential anticancer approach, but the clinical utility of current α-hGMII inhibitors is limited by their co-inhibition of human lysosomal α-mannosidase (α-hLM), resulting in abnormal storage of oligomannoses....

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Detalles Bibliográficos
Autores principales: Chen, Wei-An, Chen, Yu-Hsin, Hsieh, Chiao-Yun, Hung, Pi-Fang, Chen, Chiao-Wen, Chen, Chien-Hung, Lin, Jung-Lee, Cheng, Ting-Jen R., Hsu, Tsui-Ling, Wu, Ying-Ta, Shen, Chia-Ning, Cheng, Wei-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159088/
https://www.ncbi.nlm.nih.gov/pubmed/35733906
http://dx.doi.org/10.1039/d1sc05894k

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