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The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs
INTRODUCTION: Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159114/ https://www.ncbi.nlm.nih.gov/pubmed/35685534 http://dx.doi.org/10.1155/2022/1206914 |
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author | Molavi, Nader Rasouli-Azad, Morad Mirzaei, Hamed Matini, Amir Hassan Banafshe, Hamid Reza Valiollahzadeh, Marjan Hassanzadeh, Majid Saghazade, Ahmad Reza Abbaszadeh-Mashkani, Samira Mamsharifi, Peyman Ghaderi, Amir |
author_facet | Molavi, Nader Rasouli-Azad, Morad Mirzaei, Hamed Matini, Amir Hassan Banafshe, Hamid Reza Valiollahzadeh, Marjan Hassanzadeh, Majid Saghazade, Ahmad Reza Abbaszadeh-Mashkani, Samira Mamsharifi, Peyman Ghaderi, Amir |
author_sort | Molavi, Nader |
collection | PubMed |
description | INTRODUCTION: Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and serum lipid content in patients receiving MMTPs. MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled trial was conducted among 70 patients receiving MMTPs to receive either 1.8 × 10(9) CFU/day probiotics (n = 35) or placebo (n = 35) for 12 weeks. Clinical symptoms and metabolic profiles were measured before and after the intervention in patients receiving MMTPs. RESULTS: Compared with the placebo group, probiotic supplementation resulted in a significant improvement in the severity of depression (P < 0.05). In addition, probiotic administration significantly decreased fasting plasma glucose (FPG), total cholesterol, and low-density lipoprotein cholesterol (LDL cholesterol) (P < 0.05). Furthermore, probiotics resulted in a significant reduction in high-sensitivity C-reactive protein (hs-CRP) and a significant elevation in total antioxidant capacity (TAC) and total glutathione (GSH) levels (P < 0.05). CONCLUSION: Treatment with probiotics for 12 weeks to patients receiving MMTPs had beneficial effects on symptoms of depression, as well as several metabolic profiles. Clinical Trial Registration: this study was registered in the Iranian website (https://www.irct.ir) for clinical trials registration (https://fa.irct.ir/trial/46363/IRCT20170420033551N9). The registration date is March 22, 2020. |
format | Online Article Text |
id | pubmed-9159114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91591142022-06-07 The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs Molavi, Nader Rasouli-Azad, Morad Mirzaei, Hamed Matini, Amir Hassan Banafshe, Hamid Reza Valiollahzadeh, Marjan Hassanzadeh, Majid Saghazade, Ahmad Reza Abbaszadeh-Mashkani, Samira Mamsharifi, Peyman Ghaderi, Amir Int J Clin Pract Research Article INTRODUCTION: Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and serum lipid content in patients receiving MMTPs. MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled trial was conducted among 70 patients receiving MMTPs to receive either 1.8 × 10(9) CFU/day probiotics (n = 35) or placebo (n = 35) for 12 weeks. Clinical symptoms and metabolic profiles were measured before and after the intervention in patients receiving MMTPs. RESULTS: Compared with the placebo group, probiotic supplementation resulted in a significant improvement in the severity of depression (P < 0.05). In addition, probiotic administration significantly decreased fasting plasma glucose (FPG), total cholesterol, and low-density lipoprotein cholesterol (LDL cholesterol) (P < 0.05). Furthermore, probiotics resulted in a significant reduction in high-sensitivity C-reactive protein (hs-CRP) and a significant elevation in total antioxidant capacity (TAC) and total glutathione (GSH) levels (P < 0.05). CONCLUSION: Treatment with probiotics for 12 weeks to patients receiving MMTPs had beneficial effects on symptoms of depression, as well as several metabolic profiles. Clinical Trial Registration: this study was registered in the Iranian website (https://www.irct.ir) for clinical trials registration (https://fa.irct.ir/trial/46363/IRCT20170420033551N9). The registration date is March 22, 2020. Hindawi 2022-03-30 /pmc/articles/PMC9159114/ /pubmed/35685534 http://dx.doi.org/10.1155/2022/1206914 Text en Copyright © 2022 Nader Molavi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Molavi, Nader Rasouli-Azad, Morad Mirzaei, Hamed Matini, Amir Hassan Banafshe, Hamid Reza Valiollahzadeh, Marjan Hassanzadeh, Majid Saghazade, Ahmad Reza Abbaszadeh-Mashkani, Samira Mamsharifi, Peyman Ghaderi, Amir The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs |
title | The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs |
title_full | The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs |
title_fullStr | The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs |
title_full_unstemmed | The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs |
title_short | The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs |
title_sort | effects of probiotic supplementation on opioid-related disorder in patients under methadone maintenance treatment programs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159114/ https://www.ncbi.nlm.nih.gov/pubmed/35685534 http://dx.doi.org/10.1155/2022/1206914 |
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