Cargando…

The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs

INTRODUCTION: Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and s...

Descripción completa

Detalles Bibliográficos
Autores principales: Molavi, Nader, Rasouli-Azad, Morad, Mirzaei, Hamed, Matini, Amir Hassan, Banafshe, Hamid Reza, Valiollahzadeh, Marjan, Hassanzadeh, Majid, Saghazade, Ahmad Reza, Abbaszadeh-Mashkani, Samira, Mamsharifi, Peyman, Ghaderi, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159114/
https://www.ncbi.nlm.nih.gov/pubmed/35685534
http://dx.doi.org/10.1155/2022/1206914
_version_ 1784718980922998784
author Molavi, Nader
Rasouli-Azad, Morad
Mirzaei, Hamed
Matini, Amir Hassan
Banafshe, Hamid Reza
Valiollahzadeh, Marjan
Hassanzadeh, Majid
Saghazade, Ahmad Reza
Abbaszadeh-Mashkani, Samira
Mamsharifi, Peyman
Ghaderi, Amir
author_facet Molavi, Nader
Rasouli-Azad, Morad
Mirzaei, Hamed
Matini, Amir Hassan
Banafshe, Hamid Reza
Valiollahzadeh, Marjan
Hassanzadeh, Majid
Saghazade, Ahmad Reza
Abbaszadeh-Mashkani, Samira
Mamsharifi, Peyman
Ghaderi, Amir
author_sort Molavi, Nader
collection PubMed
description INTRODUCTION: Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and serum lipid content in patients receiving MMTPs. MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled trial was conducted among 70 patients receiving MMTPs to receive either 1.8 × 10(9) CFU/day probiotics (n = 35) or placebo (n = 35) for 12 weeks. Clinical symptoms and metabolic profiles were measured before and after the intervention in patients receiving MMTPs. RESULTS: Compared with the placebo group, probiotic supplementation resulted in a significant improvement in the severity of depression (P < 0.05). In addition, probiotic administration significantly decreased fasting plasma glucose (FPG), total cholesterol, and low-density lipoprotein cholesterol (LDL cholesterol) (P < 0.05). Furthermore, probiotics resulted in a significant reduction in high-sensitivity C-reactive protein (hs-CRP) and a significant elevation in total antioxidant capacity (TAC) and total glutathione (GSH) levels (P < 0.05). CONCLUSION: Treatment with probiotics for 12 weeks to patients receiving MMTPs had beneficial effects on symptoms of depression, as well as several metabolic profiles. Clinical Trial Registration: this study was registered in the Iranian website (https://www.irct.ir) for clinical trials registration (https://fa.irct.ir/trial/46363/IRCT20170420033551N9). The registration date is March 22, 2020.
format Online
Article
Text
id pubmed-9159114
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-91591142022-06-07 The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs Molavi, Nader Rasouli-Azad, Morad Mirzaei, Hamed Matini, Amir Hassan Banafshe, Hamid Reza Valiollahzadeh, Marjan Hassanzadeh, Majid Saghazade, Ahmad Reza Abbaszadeh-Mashkani, Samira Mamsharifi, Peyman Ghaderi, Amir Int J Clin Pract Research Article INTRODUCTION: Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and serum lipid content in patients receiving MMTPs. MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled trial was conducted among 70 patients receiving MMTPs to receive either 1.8 × 10(9) CFU/day probiotics (n = 35) or placebo (n = 35) for 12 weeks. Clinical symptoms and metabolic profiles were measured before and after the intervention in patients receiving MMTPs. RESULTS: Compared with the placebo group, probiotic supplementation resulted in a significant improvement in the severity of depression (P < 0.05). In addition, probiotic administration significantly decreased fasting plasma glucose (FPG), total cholesterol, and low-density lipoprotein cholesterol (LDL cholesterol) (P < 0.05). Furthermore, probiotics resulted in a significant reduction in high-sensitivity C-reactive protein (hs-CRP) and a significant elevation in total antioxidant capacity (TAC) and total glutathione (GSH) levels (P < 0.05). CONCLUSION: Treatment with probiotics for 12 weeks to patients receiving MMTPs had beneficial effects on symptoms of depression, as well as several metabolic profiles. Clinical Trial Registration: this study was registered in the Iranian website (https://www.irct.ir) for clinical trials registration (https://fa.irct.ir/trial/46363/IRCT20170420033551N9). The registration date is March 22, 2020. Hindawi 2022-03-30 /pmc/articles/PMC9159114/ /pubmed/35685534 http://dx.doi.org/10.1155/2022/1206914 Text en Copyright © 2022 Nader Molavi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Molavi, Nader
Rasouli-Azad, Morad
Mirzaei, Hamed
Matini, Amir Hassan
Banafshe, Hamid Reza
Valiollahzadeh, Marjan
Hassanzadeh, Majid
Saghazade, Ahmad Reza
Abbaszadeh-Mashkani, Samira
Mamsharifi, Peyman
Ghaderi, Amir
The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs
title The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs
title_full The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs
title_fullStr The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs
title_full_unstemmed The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs
title_short The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs
title_sort effects of probiotic supplementation on opioid-related disorder in patients under methadone maintenance treatment programs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159114/
https://www.ncbi.nlm.nih.gov/pubmed/35685534
http://dx.doi.org/10.1155/2022/1206914
work_keys_str_mv AT molavinader theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT rasouliazadmorad theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT mirzaeihamed theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT matiniamirhassan theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT banafshehamidreza theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT valiollahzadehmarjan theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT hassanzadehmajid theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT saghazadeahmadreza theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT abbaszadehmashkanisamira theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT mamsharifipeyman theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT ghaderiamir theeffectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT molavinader effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT rasouliazadmorad effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT mirzaeihamed effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT matiniamirhassan effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT banafshehamidreza effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT valiollahzadehmarjan effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT hassanzadehmajid effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT saghazadeahmadreza effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT abbaszadehmashkanisamira effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT mamsharifipeyman effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms
AT ghaderiamir effectsofprobioticsupplementationonopioidrelateddisorderinpatientsundermethadonemaintenancetreatmentprograms