Human embryonic stem cell-derived neural crest model unveils CD55 as a cancer stem cell regulator for therapeutic targeting in MYCN-amplified neuroblastoma

BACKGROUND: Neuroblastoma (NB) is a common childhood malignant tumor of neural crest (NC) origin with remarkable heterogeneity in outcomes. Amplification of the oncogene MYCN is strongly associated with highly malignant behaviour and poor prognosis. METHODS: This study aims to use a human embryonic...

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Detalles Bibliográficos
Autores principales: Weng, Zhihui, Lin, Jiacheng, He, Jiaozi, Gao, Lin, Lin, Sien, Tsang, Lai Ling, Zhang, Hang, He, Xiaoyan, Wang, Guang, Yang, Xuesong, Zhou, Hu, Zhao, Hui, Li, Gang, Zou, Lin, Jiang, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159429/
https://www.ncbi.nlm.nih.gov/pubmed/34655293
http://dx.doi.org/10.1093/neuonc/noab241

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