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Linear viscoelastic properties of the vertex model for epithelial tissues

Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells actively tune their mechanical properties to change...

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Detalles Bibliográficos
Autores principales: Tong, Sijie, Singh, Navreeta K., Sknepnek, Rastko, Košmrlj, Andrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159552/
https://www.ncbi.nlm.nih.gov/pubmed/35587514
http://dx.doi.org/10.1371/journal.pcbi.1010135
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author Tong, Sijie
Singh, Navreeta K.
Sknepnek, Rastko
Košmrlj, Andrej
author_facet Tong, Sijie
Singh, Navreeta K.
Sknepnek, Rastko
Košmrlj, Andrej
author_sort Tong, Sijie
collection PubMed
description Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells actively tune their mechanical properties to change the overall response of the tissue, e.g., from solid-like to fluid-like. Mesoscopic mechanical properties of epithelia are commonly modeled with the vertex model. While previous studies have predominantly focused on the rheological properties of the vertex model at long time scales, we systematically studied the full dynamic range by applying small oscillatory shear and bulk deformations in both solid-like and fluid-like phases for regular hexagonal and disordered cell configurations. We found that the shear and bulk responses in the fluid and solid phases can be described by standard spring-dashpot viscoelastic models. Furthermore, the solid-fluid transition can be tuned by applying pre-deformation to the system. Our study provides insights into the mechanisms by which epithelia can regulate their rich rheological behavior.
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spelling pubmed-91595522022-06-02 Linear viscoelastic properties of the vertex model for epithelial tissues Tong, Sijie Singh, Navreeta K. Sknepnek, Rastko Košmrlj, Andrej PLoS Comput Biol Research Article Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells actively tune their mechanical properties to change the overall response of the tissue, e.g., from solid-like to fluid-like. Mesoscopic mechanical properties of epithelia are commonly modeled with the vertex model. While previous studies have predominantly focused on the rheological properties of the vertex model at long time scales, we systematically studied the full dynamic range by applying small oscillatory shear and bulk deformations in both solid-like and fluid-like phases for regular hexagonal and disordered cell configurations. We found that the shear and bulk responses in the fluid and solid phases can be described by standard spring-dashpot viscoelastic models. Furthermore, the solid-fluid transition can be tuned by applying pre-deformation to the system. Our study provides insights into the mechanisms by which epithelia can regulate their rich rheological behavior. Public Library of Science 2022-05-19 /pmc/articles/PMC9159552/ /pubmed/35587514 http://dx.doi.org/10.1371/journal.pcbi.1010135 Text en © 2022 Tong et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tong, Sijie
Singh, Navreeta K.
Sknepnek, Rastko
Košmrlj, Andrej
Linear viscoelastic properties of the vertex model for epithelial tissues
title Linear viscoelastic properties of the vertex model for epithelial tissues
title_full Linear viscoelastic properties of the vertex model for epithelial tissues
title_fullStr Linear viscoelastic properties of the vertex model for epithelial tissues
title_full_unstemmed Linear viscoelastic properties of the vertex model for epithelial tissues
title_short Linear viscoelastic properties of the vertex model for epithelial tissues
title_sort linear viscoelastic properties of the vertex model for epithelial tissues
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159552/
https://www.ncbi.nlm.nih.gov/pubmed/35587514
http://dx.doi.org/10.1371/journal.pcbi.1010135
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