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Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
BACKGROUND: Inositol is a sugar‐alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159559/ https://www.ncbi.nlm.nih.gov/pubmed/35664247 http://dx.doi.org/10.1002/osp4.569 |
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author | Zarezadeh, Meysam Dehghani, Azadeh Faghfouri, Amir Hossein Radkhah, Nima Naemi Kermanshahi, Mohammad Hamedi Kalajahi, Fatemeh Mohammadzadeh Honarvar, Niyaz Ghoreishi, Zohreh Ostadrahimi, Alireza Ebrahimi Mamaghani, Mehrangiz |
author_facet | Zarezadeh, Meysam Dehghani, Azadeh Faghfouri, Amir Hossein Radkhah, Nima Naemi Kermanshahi, Mohammad Hamedi Kalajahi, Fatemeh Mohammadzadeh Honarvar, Niyaz Ghoreishi, Zohreh Ostadrahimi, Alireza Ebrahimi Mamaghani, Mehrangiz |
author_sort | Zarezadeh, Meysam |
collection | PubMed |
description | BACKGROUND: Inositol is a sugar‐alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by improving insulin sensitivity, the benefit of inositol supplementation in patients with overweight and obesity is not completely understood. This study aimed to assess the impact of inositol supplementation on body mass index (BMI) through a systematic review and meta‐analysis of controlled clinical trials. METHODS: A systematic search was performed to August 2021 in the following databases: PubMed‐Medline, Embase, Web of Science and Scopus. Fifteen controlled clinical trials investigating the effect of inositol on adult's BMI were finally included in the study. A random‐effects model was employed to estimate the effect size. Subgroup analysis was performed by dose, duration, age, type of inositol. Meta‐regression was used to investigate presence of any linear relationship. Begg's and Egger's tests were carried out to detect small study effect. RESULTS: The results of pooled analysis showed that inositol supplementation significantly decreased BMI scores (WMD = −0.41 kg/m(2); 95% CI: −0.78, −0.04; p = 0.028). Subgroup analysis was performed to identify the source of heterogeneity among studies (I (2) = 73.9%, p < 0.001), demonstrating supplementation duration, baseline BMI, mean age of participants, type of inositol and dosage were potential sources of heterogeneity. The effect of intervention was more clinically significant in participants with polycystic ovary syndrome (PCOS) and overweight/obesity. Inositol in the form of myo‐inositol (MI) had stronger effect on BMI reduction. CONCLUSION: The meta‐analysis suggests that oral inositol supplementation has positive effect on BMI reduction. Inositol supplementation could be considered as an adjunct treatment to improve body mass index. |
format | Online Article Text |
id | pubmed-9159559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91595592022-06-04 Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials Zarezadeh, Meysam Dehghani, Azadeh Faghfouri, Amir Hossein Radkhah, Nima Naemi Kermanshahi, Mohammad Hamedi Kalajahi, Fatemeh Mohammadzadeh Honarvar, Niyaz Ghoreishi, Zohreh Ostadrahimi, Alireza Ebrahimi Mamaghani, Mehrangiz Obes Sci Pract Reviews BACKGROUND: Inositol is a sugar‐alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by improving insulin sensitivity, the benefit of inositol supplementation in patients with overweight and obesity is not completely understood. This study aimed to assess the impact of inositol supplementation on body mass index (BMI) through a systematic review and meta‐analysis of controlled clinical trials. METHODS: A systematic search was performed to August 2021 in the following databases: PubMed‐Medline, Embase, Web of Science and Scopus. Fifteen controlled clinical trials investigating the effect of inositol on adult's BMI were finally included in the study. A random‐effects model was employed to estimate the effect size. Subgroup analysis was performed by dose, duration, age, type of inositol. Meta‐regression was used to investigate presence of any linear relationship. Begg's and Egger's tests were carried out to detect small study effect. RESULTS: The results of pooled analysis showed that inositol supplementation significantly decreased BMI scores (WMD = −0.41 kg/m(2); 95% CI: −0.78, −0.04; p = 0.028). Subgroup analysis was performed to identify the source of heterogeneity among studies (I (2) = 73.9%, p < 0.001), demonstrating supplementation duration, baseline BMI, mean age of participants, type of inositol and dosage were potential sources of heterogeneity. The effect of intervention was more clinically significant in participants with polycystic ovary syndrome (PCOS) and overweight/obesity. Inositol in the form of myo‐inositol (MI) had stronger effect on BMI reduction. CONCLUSION: The meta‐analysis suggests that oral inositol supplementation has positive effect on BMI reduction. Inositol supplementation could be considered as an adjunct treatment to improve body mass index. John Wiley and Sons Inc. 2021-10-22 /pmc/articles/PMC9159559/ /pubmed/35664247 http://dx.doi.org/10.1002/osp4.569 Text en © 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Zarezadeh, Meysam Dehghani, Azadeh Faghfouri, Amir Hossein Radkhah, Nima Naemi Kermanshahi, Mohammad Hamedi Kalajahi, Fatemeh Mohammadzadeh Honarvar, Niyaz Ghoreishi, Zohreh Ostadrahimi, Alireza Ebrahimi Mamaghani, Mehrangiz Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials |
title | Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials |
title_full | Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials |
title_fullStr | Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials |
title_full_unstemmed | Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials |
title_short | Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials |
title_sort | inositol supplementation and body mass index: a systematic review and meta‐analysis of randomized clinical trials |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159559/ https://www.ncbi.nlm.nih.gov/pubmed/35664247 http://dx.doi.org/10.1002/osp4.569 |
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