Cargando…

Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials

BACKGROUND: Inositol is a sugar‐alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by...

Descripción completa

Detalles Bibliográficos
Autores principales: Zarezadeh, Meysam, Dehghani, Azadeh, Faghfouri, Amir Hossein, Radkhah, Nima, Naemi Kermanshahi, Mohammad, Hamedi Kalajahi, Fatemeh, Mohammadzadeh Honarvar, Niyaz, Ghoreishi, Zohreh, Ostadrahimi, Alireza, Ebrahimi Mamaghani, Mehrangiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159559/
https://www.ncbi.nlm.nih.gov/pubmed/35664247
http://dx.doi.org/10.1002/osp4.569
_version_ 1784719077630017536
author Zarezadeh, Meysam
Dehghani, Azadeh
Faghfouri, Amir Hossein
Radkhah, Nima
Naemi Kermanshahi, Mohammad
Hamedi Kalajahi, Fatemeh
Mohammadzadeh Honarvar, Niyaz
Ghoreishi, Zohreh
Ostadrahimi, Alireza
Ebrahimi Mamaghani, Mehrangiz
author_facet Zarezadeh, Meysam
Dehghani, Azadeh
Faghfouri, Amir Hossein
Radkhah, Nima
Naemi Kermanshahi, Mohammad
Hamedi Kalajahi, Fatemeh
Mohammadzadeh Honarvar, Niyaz
Ghoreishi, Zohreh
Ostadrahimi, Alireza
Ebrahimi Mamaghani, Mehrangiz
author_sort Zarezadeh, Meysam
collection PubMed
description BACKGROUND: Inositol is a sugar‐alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by improving insulin sensitivity, the benefit of inositol supplementation in patients with overweight and obesity is not completely understood. This study aimed to assess the impact of inositol supplementation on body mass index (BMI) through a systematic review and meta‐analysis of controlled clinical trials. METHODS: A systematic search was performed to August 2021 in the following databases: PubMed‐Medline, Embase, Web of Science and Scopus. Fifteen controlled clinical trials investigating the effect of inositol on adult's BMI were finally included in the study. A random‐effects model was employed to estimate the effect size. Subgroup analysis was performed by dose, duration, age, type of inositol. Meta‐regression was used to investigate presence of any linear relationship. Begg's and Egger's tests were carried out to detect small study effect. RESULTS: The results of pooled analysis showed that inositol supplementation significantly decreased BMI scores (WMD = −0.41 kg/m(2); 95% CI: −0.78, −0.04; p = 0.028). Subgroup analysis was performed to identify the source of heterogeneity among studies (I (2) = 73.9%, p < 0.001), demonstrating supplementation duration, baseline BMI, mean age of participants, type of inositol and dosage were potential sources of heterogeneity. The effect of intervention was more clinically significant in participants with polycystic ovary syndrome (PCOS) and overweight/obesity. Inositol in the form of myo‐inositol (MI) had stronger effect on BMI reduction. CONCLUSION: The meta‐analysis suggests that oral inositol supplementation has positive effect on BMI reduction. Inositol supplementation could be considered as an adjunct treatment to improve body mass index.
format Online
Article
Text
id pubmed-9159559
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-91595592022-06-04 Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials Zarezadeh, Meysam Dehghani, Azadeh Faghfouri, Amir Hossein Radkhah, Nima Naemi Kermanshahi, Mohammad Hamedi Kalajahi, Fatemeh Mohammadzadeh Honarvar, Niyaz Ghoreishi, Zohreh Ostadrahimi, Alireza Ebrahimi Mamaghani, Mehrangiz Obes Sci Pract Reviews BACKGROUND: Inositol is a sugar‐alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by improving insulin sensitivity, the benefit of inositol supplementation in patients with overweight and obesity is not completely understood. This study aimed to assess the impact of inositol supplementation on body mass index (BMI) through a systematic review and meta‐analysis of controlled clinical trials. METHODS: A systematic search was performed to August 2021 in the following databases: PubMed‐Medline, Embase, Web of Science and Scopus. Fifteen controlled clinical trials investigating the effect of inositol on adult's BMI were finally included in the study. A random‐effects model was employed to estimate the effect size. Subgroup analysis was performed by dose, duration, age, type of inositol. Meta‐regression was used to investigate presence of any linear relationship. Begg's and Egger's tests were carried out to detect small study effect. RESULTS: The results of pooled analysis showed that inositol supplementation significantly decreased BMI scores (WMD = −0.41 kg/m(2); 95% CI: −0.78, −0.04; p = 0.028). Subgroup analysis was performed to identify the source of heterogeneity among studies (I (2) = 73.9%, p < 0.001), demonstrating supplementation duration, baseline BMI, mean age of participants, type of inositol and dosage were potential sources of heterogeneity. The effect of intervention was more clinically significant in participants with polycystic ovary syndrome (PCOS) and overweight/obesity. Inositol in the form of myo‐inositol (MI) had stronger effect on BMI reduction. CONCLUSION: The meta‐analysis suggests that oral inositol supplementation has positive effect on BMI reduction. Inositol supplementation could be considered as an adjunct treatment to improve body mass index. John Wiley and Sons Inc. 2021-10-22 /pmc/articles/PMC9159559/ /pubmed/35664247 http://dx.doi.org/10.1002/osp4.569 Text en © 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Zarezadeh, Meysam
Dehghani, Azadeh
Faghfouri, Amir Hossein
Radkhah, Nima
Naemi Kermanshahi, Mohammad
Hamedi Kalajahi, Fatemeh
Mohammadzadeh Honarvar, Niyaz
Ghoreishi, Zohreh
Ostadrahimi, Alireza
Ebrahimi Mamaghani, Mehrangiz
Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
title Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
title_full Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
title_fullStr Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
title_full_unstemmed Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
title_short Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
title_sort inositol supplementation and body mass index: a systematic review and meta‐analysis of randomized clinical trials
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159559/
https://www.ncbi.nlm.nih.gov/pubmed/35664247
http://dx.doi.org/10.1002/osp4.569
work_keys_str_mv AT zarezadehmeysam inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT dehghaniazadeh inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT faghfouriamirhossein inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT radkhahnima inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT naemikermanshahimohammad inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT hamedikalajahifatemeh inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT mohammadzadehhonarvarniyaz inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT ghoreishizohreh inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT ostadrahimialireza inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials
AT ebrahimimamaghanimehrangiz inositolsupplementationandbodymassindexasystematicreviewandmetaanalysisofrandomizedclinicaltrials