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Alternative Polyadenylation Utilization Results in Ribosome Assembly and mRNA Translation Deficiencies in a Model for Muscle Aging

Aging-associated muscle wasting is regulated by multiple molecular processes, whereby aberrant mRNA processing regulation induces muscle wasting. The poly(A)-binding protein nuclear 1 (PABPN1) regulates polyadenylation site (PAS) utilization, in the absence of PABPN1 the alternative polyadenylation...

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Detalles Bibliográficos
Autores principales:	Mei, Hailiang, Boom, Jasper, el Abdellaoui, Salma, Abdelmohsen, Kotb, Munk, Rachel, Martindale, Jennifer L, Kloet, Susan, Kielbasa, Szymone M, Sharp, Thomas H, Gorospe, Myriam, Raz, Vered
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	THE JOURNAL OF GERONTOLOGY: Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159670/ https://www.ncbi.nlm.nih.gov/pubmed/35245938 http://dx.doi.org/10.1093/gerona/glac058

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