A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy

Although immobility is a common cause of muscle atrophy, the mechanism underlying this causality is unclear. We here show that Krüppel-like factor 15 (KLF15) and IL-6 are upregulated in skeletal muscle of limb-immobilized mice and that mice with KLF15 deficiency in skeletal muscle or with systemic I...

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Detalles Bibliográficos
Autores principales: Hirata, Yu, Nomura, Kazuhiro, Kato, Daisuke, Tachibana, Yoshihisa, Niikura, Takahiro, Uchiyama, Kana, Hosooka, Tetsuya, Fukui, Tomoaki, Oe, Keisuke, Kuroda, Ryosuke, Hara, Yuji, Adachi, Takahiro, Shibasaki, Koji, Wake, Hiroaki, Ogawa, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159676/
https://www.ncbi.nlm.nih.gov/pubmed/35290243
http://dx.doi.org/10.1172/JCI154611

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