Modeling mutational effects on biochemical phenotypes using convolutional neural networks: application to SARS-CoV-2

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Deep mutational scanning (DMS) experiments have been performed on SARS-CoV-2’s spike receptor-binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2) zinc-binding peptidase domain—both central players in viral infection and evolution and antibody evasion—quantifying how mutations impac...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Gamazon, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159778/
https://www.ncbi.nlm.nih.gov/pubmed/35669036
http://dx.doi.org/10.1016/j.isci.2022.104500

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