The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete

The Lyme disease spirochete Borrelia burgdorferi, encodes an elaborate antigenic variation system that promotes the ongoing variation of a major surface lipoprotein, VlsE. Changes in VlsE are continual and always one step ahead of the host acquired immune system, which requires 1–2 weeks to generate...

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Detalles Bibliográficos
Autores principales: Castellanos, Mildred, Verhey, Theodore B., Goldstein, Madeleine, Chaconas, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159922/
https://www.ncbi.nlm.nih.gov/pubmed/35663861
http://dx.doi.org/10.3389/fmicb.2022.888494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159922/
https://www.ncbi.nlm.nih.gov/pubmed/35663861
http://dx.doi.org/10.3389/fmicb.2022.888494

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