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MCM complexes are barriers that restrict cohesin-mediated loop extrusion

Eukaryotic genomes are compacted into loops and topologically associating domains (TADs)(1–3), which contribute to transcription, recombination and genomic stability(4,5). Cohesin extrudes DNA into loops that are thought to lengthen until CTCF boundaries are encountered(6–12). Little is known about...

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Detalles Bibliográficos
Autores principales:	Dequeker, Bart J. H., Scherr, Matthias J., Brandão, Hugo B., Gassler, Johanna, Powell, Sean, Gaspar, Imre, Flyamer, Ilya M., Lalic, Aleksandar, Tang, Wen, Stocsits, Roman, Davidson, Iain F., Peters, Jan-Michael, Duderstadt, Karl E., Mirny, Leonid A., Tachibana, Kikuë
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159944/ https://www.ncbi.nlm.nih.gov/pubmed/35585235 http://dx.doi.org/10.1038/s41586-022-04730-0

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