Fundamental immune–oncogenicity trade-offs define driver mutation fitness

Missense driver mutations in cancer are concentrated in a few hotspots(1). Various mechanisms have been proposed to explain this skew, including biased mutational processes(2), phenotypic differences(3–6) and immunoediting of neoantigens(7,8); however, to our knowledge, no existing model weighs the...

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Detalles Bibliográficos
Autores principales: Hoyos, David, Zappasodi, Roberta, Schulze, Isabell, Sethna, Zachary, de Andrade, Kelvin César, Bajorin, Dean F., Bandlamudi, Chaitanya, Callahan, Margaret K., Funt, Samuel A., Hadrup, Sine R., Holm, Jeppe S., Rosenberg, Jonathan E., Shah, Sohrab P., Vázquez-García, Ignacio, Weigelt, Britta, Wu, Michelle, Zamarin, Dmitriy, Campitelli, Laura F., Osborne, Edward J., Klinger, Mark, Robins, Harlan S., Khincha, Payal P., Savage, Sharon A., Balachandran, Vinod P., Wolchok, Jedd D., Hellmann, Matthew D., Merghoub, Taha, Levine, Arnold J., Łuksza, Marta, Greenbaum, Benjamin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159948/
https://www.ncbi.nlm.nih.gov/pubmed/35545680
http://dx.doi.org/10.1038/s41586-022-04696-z

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