Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation

Protein degradation, a major eukaryotic response to cellular signals, is subject to numerous layers of regulation. In yeast, the evolutionarily conserved GID E3 ligase mediates glucose-induced degradation of fructose-1,6-bisphosphatase (Fbp1), malate dehydrogenase (Mdh2), and other gluconeogenic enz...

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Detalles Bibliográficos
Autores principales: Qiao, Shuai, Lee, Chia-Wei, Sherpa, Dawafuti, Chrustowicz, Jakub, Cheng, Jingdong, Duennebacke, Maximilian, Steigenberger, Barbara, Karayel, Ozge, Vu, Duc Tung, von Gronau, Susanne, Mann, Matthias, Wilfling, Florian, Schulman, Brenda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160049/
https://www.ncbi.nlm.nih.gov/pubmed/35650207
http://dx.doi.org/10.1038/s41467-022-30803-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160049/
https://www.ncbi.nlm.nih.gov/pubmed/35650207
http://dx.doi.org/10.1038/s41467-022-30803-9

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