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The use of quantitative pupillometry in patients with pituitary tumors: a technical note
BACKGROUND: Pituitary tumors may cause compression of the optic chiasm, resulting in decreased visual acuity. Therefore, decompression of the optic chiasm is a major goal of surgical treatment in such patients. Quantitative pupillometry has been used in various clinical settings for assessing the op...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160135/ https://www.ncbi.nlm.nih.gov/pubmed/35445853 http://dx.doi.org/10.1007/s00701-022-05214-w |
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author | Lenga, Pavlina Jakobs, Martin Jesser, Jessica Trong, Philip Dao Unterberg, Andreas W. Beynon, Christopher |
author_facet | Lenga, Pavlina Jakobs, Martin Jesser, Jessica Trong, Philip Dao Unterberg, Andreas W. Beynon, Christopher |
author_sort | Lenga, Pavlina |
collection | PubMed |
description | BACKGROUND: Pituitary tumors may cause compression of the optic chiasm, resulting in decreased visual acuity. Therefore, decompression of the optic chiasm is a major goal of surgical treatment in such patients. Quantitative pupillometry has been used in various clinical settings for assessing the optic system but has not been applied in patients with pituitary tumors. This study aimed to evaluate the potential of this technique to improve treatment modalities in patients undergoing surgical resection of pituitary tumors. METHOD: Pupillometry using the automated NPi 200® Pupillometer was performed in seven patients who underwent surgical resection of large pituitary tumors at the University of Heidelberg in 2018. The neurological pupil index (NPi) was assessed preoperatively and postoperatively, and correlations with visual acuity and magnetic resonance imaging (MRI) findings regarding optic chiasm compression were determined. RESULTS: All patients experienced visual disturbance due to a large pituitary tumor. The NPi was < 4.0 in all patients in at least one pupil. Intraoperative MRI demonstrated successful decompression of the optic chiasm in all cases. Postoperatively, the NPi values increased, and this increase was correlated with improved visual acuity. CONCLUSIONS: We found that quantitative pupillometry can detect optic chiasm compression in patients with pituitary tumors. Furthermore, postoperative improvement of NPi values may indicate sufficient decompression of the optic chiasm. Further studies are warranted to substantiate the granularity of this technique to gain valuable information for patients with pituitary tumors who are indicated for surgery. |
format | Online Article Text |
id | pubmed-9160135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-91601352022-06-03 The use of quantitative pupillometry in patients with pituitary tumors: a technical note Lenga, Pavlina Jakobs, Martin Jesser, Jessica Trong, Philip Dao Unterberg, Andreas W. Beynon, Christopher Acta Neurochir (Wien) Technical Note - Pituitaries BACKGROUND: Pituitary tumors may cause compression of the optic chiasm, resulting in decreased visual acuity. Therefore, decompression of the optic chiasm is a major goal of surgical treatment in such patients. Quantitative pupillometry has been used in various clinical settings for assessing the optic system but has not been applied in patients with pituitary tumors. This study aimed to evaluate the potential of this technique to improve treatment modalities in patients undergoing surgical resection of pituitary tumors. METHOD: Pupillometry using the automated NPi 200® Pupillometer was performed in seven patients who underwent surgical resection of large pituitary tumors at the University of Heidelberg in 2018. The neurological pupil index (NPi) was assessed preoperatively and postoperatively, and correlations with visual acuity and magnetic resonance imaging (MRI) findings regarding optic chiasm compression were determined. RESULTS: All patients experienced visual disturbance due to a large pituitary tumor. The NPi was < 4.0 in all patients in at least one pupil. Intraoperative MRI demonstrated successful decompression of the optic chiasm in all cases. Postoperatively, the NPi values increased, and this increase was correlated with improved visual acuity. CONCLUSIONS: We found that quantitative pupillometry can detect optic chiasm compression in patients with pituitary tumors. Furthermore, postoperative improvement of NPi values may indicate sufficient decompression of the optic chiasm. Further studies are warranted to substantiate the granularity of this technique to gain valuable information for patients with pituitary tumors who are indicated for surgery. Springer Vienna 2022-04-21 2022 /pmc/articles/PMC9160135/ /pubmed/35445853 http://dx.doi.org/10.1007/s00701-022-05214-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Technical Note - Pituitaries Lenga, Pavlina Jakobs, Martin Jesser, Jessica Trong, Philip Dao Unterberg, Andreas W. Beynon, Christopher The use of quantitative pupillometry in patients with pituitary tumors: a technical note |
title | The use of quantitative pupillometry in patients with pituitary tumors: a technical note |
title_full | The use of quantitative pupillometry in patients with pituitary tumors: a technical note |
title_fullStr | The use of quantitative pupillometry in patients with pituitary tumors: a technical note |
title_full_unstemmed | The use of quantitative pupillometry in patients with pituitary tumors: a technical note |
title_short | The use of quantitative pupillometry in patients with pituitary tumors: a technical note |
title_sort | use of quantitative pupillometry in patients with pituitary tumors: a technical note |
topic | Technical Note - Pituitaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160135/ https://www.ncbi.nlm.nih.gov/pubmed/35445853 http://dx.doi.org/10.1007/s00701-022-05214-w |
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