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Epigenome-wide DNA methylation in obsessive-compulsive disorder
In adult patients with obsessive-compulsive disorder (OCD), altered DNA methylation has been discerned in several candidate genes, while DNA methylation on an epigenome-wide level has been investigated in only one Chinese study so far. Here, an epigenome-wide association study (EWAS) was performed i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160220/ https://www.ncbi.nlm.nih.gov/pubmed/35650177 http://dx.doi.org/10.1038/s41398-022-01996-w |
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author | Schiele, Miriam A. Lipovsek, Jan Schlosser, Pascal Soutschek, Michael Schratt, Gerhard Zaudig, Michael Berberich, Götz Köttgen, Anna Domschke, Katharina |
author_facet | Schiele, Miriam A. Lipovsek, Jan Schlosser, Pascal Soutschek, Michael Schratt, Gerhard Zaudig, Michael Berberich, Götz Köttgen, Anna Domschke, Katharina |
author_sort | Schiele, Miriam A. |
collection | PubMed |
description | In adult patients with obsessive-compulsive disorder (OCD), altered DNA methylation has been discerned in several candidate genes, while DNA methylation on an epigenome-wide level has been investigated in only one Chinese study so far. Here, an epigenome-wide association study (EWAS) was performed in a sample of 76 OCD patients of European ancestry (37 women, age ± SD: 33.51 ± 10.92 years) and 76 sex- and age-matched healthy controls for the first time using the Illumina MethylationEPIC BeadChip. After quality control, nine epigenome-wide significant quantitative trait methylation sites (QTMs) and 21 suggestive hits were discerned in the final sample of 68 patients and 68 controls. The top hit (cg24159721) and four other significant QTMs (cg11894324, cg01070250, cg11330075, cg15174812) map to the region of the microRNA 12136 gene (MIR12136). Two additional significant CpG sites (cg05740793, cg20450977) are located in the flanking region of the MT-RNR2 (humanin) like 8 gene (MT-RNRL8), while two further QTMs (cg16267121, cg15890734) map to the regions of the MT-RNR2 (humanin) like 3 (MT-RNRL3) and MT-RNR2 (humanin) like 2 (MT-RNRL2) genes. Provided replication of the present findings in larger samples, the identified QTMs might provide more biological insight into the pathogenesis of OCD and thereby could in the future serve as peripheral epigenetic markers of OCD risk with the potential to inform targeted preventive and therapeutic efforts. |
format | Online Article Text |
id | pubmed-9160220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91602202022-06-03 Epigenome-wide DNA methylation in obsessive-compulsive disorder Schiele, Miriam A. Lipovsek, Jan Schlosser, Pascal Soutschek, Michael Schratt, Gerhard Zaudig, Michael Berberich, Götz Köttgen, Anna Domschke, Katharina Transl Psychiatry Article In adult patients with obsessive-compulsive disorder (OCD), altered DNA methylation has been discerned in several candidate genes, while DNA methylation on an epigenome-wide level has been investigated in only one Chinese study so far. Here, an epigenome-wide association study (EWAS) was performed in a sample of 76 OCD patients of European ancestry (37 women, age ± SD: 33.51 ± 10.92 years) and 76 sex- and age-matched healthy controls for the first time using the Illumina MethylationEPIC BeadChip. After quality control, nine epigenome-wide significant quantitative trait methylation sites (QTMs) and 21 suggestive hits were discerned in the final sample of 68 patients and 68 controls. The top hit (cg24159721) and four other significant QTMs (cg11894324, cg01070250, cg11330075, cg15174812) map to the region of the microRNA 12136 gene (MIR12136). Two additional significant CpG sites (cg05740793, cg20450977) are located in the flanking region of the MT-RNR2 (humanin) like 8 gene (MT-RNRL8), while two further QTMs (cg16267121, cg15890734) map to the regions of the MT-RNR2 (humanin) like 3 (MT-RNRL3) and MT-RNR2 (humanin) like 2 (MT-RNRL2) genes. Provided replication of the present findings in larger samples, the identified QTMs might provide more biological insight into the pathogenesis of OCD and thereby could in the future serve as peripheral epigenetic markers of OCD risk with the potential to inform targeted preventive and therapeutic efforts. Nature Publishing Group UK 2022-06-01 /pmc/articles/PMC9160220/ /pubmed/35650177 http://dx.doi.org/10.1038/s41398-022-01996-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Schiele, Miriam A. Lipovsek, Jan Schlosser, Pascal Soutschek, Michael Schratt, Gerhard Zaudig, Michael Berberich, Götz Köttgen, Anna Domschke, Katharina Epigenome-wide DNA methylation in obsessive-compulsive disorder |
title | Epigenome-wide DNA methylation in obsessive-compulsive disorder |
title_full | Epigenome-wide DNA methylation in obsessive-compulsive disorder |
title_fullStr | Epigenome-wide DNA methylation in obsessive-compulsive disorder |
title_full_unstemmed | Epigenome-wide DNA methylation in obsessive-compulsive disorder |
title_short | Epigenome-wide DNA methylation in obsessive-compulsive disorder |
title_sort | epigenome-wide dna methylation in obsessive-compulsive disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160220/ https://www.ncbi.nlm.nih.gov/pubmed/35650177 http://dx.doi.org/10.1038/s41398-022-01996-w |
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