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The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals

Communication between the central nervous system (CNS) and the immune system has gained much attention for its fundamental role in the development of chronic and pathological pain in humans and rodent models. Following peripheral nerve injury, neuroimmune signaling within the CNS plays an important...

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Autores principales: Johnston, Charlotte H., Whittaker, Alexandra L., Franklin, Samantha H., Hutchinson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160236/
https://www.ncbi.nlm.nih.gov/pubmed/35663552
http://dx.doi.org/10.3389/fnins.2022.887042
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author Johnston, Charlotte H.
Whittaker, Alexandra L.
Franklin, Samantha H.
Hutchinson, Mark R.
author_facet Johnston, Charlotte H.
Whittaker, Alexandra L.
Franklin, Samantha H.
Hutchinson, Mark R.
author_sort Johnston, Charlotte H.
collection PubMed
description Communication between the central nervous system (CNS) and the immune system has gained much attention for its fundamental role in the development of chronic and pathological pain in humans and rodent models. Following peripheral nerve injury, neuroimmune signaling within the CNS plays an important role in the pathophysiological changes in pain sensitivity that lead to chronic pain. In production animals, routine husbandry procedures such as tail docking and castration, often involve some degree of inflammation and peripheral nerve injury and consequently may lead to chronic pain. Our understanding of chronic pain in animals is limited by the difficulty in measuring this pathological pain state. In light of this, we have reviewed the current understanding of chronic pain in production animals. We discuss our ability to measure pain and the implications this has on animal welfare and production outcomes. Further research into the neuroimmune interface in production animals will improve our fundamental understanding of chronic pain and better inform human clinical pain management and animal husbandry practices and interventions.
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spelling pubmed-91602362022-06-03 The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals Johnston, Charlotte H. Whittaker, Alexandra L. Franklin, Samantha H. Hutchinson, Mark R. Front Neurosci Neuroscience Communication between the central nervous system (CNS) and the immune system has gained much attention for its fundamental role in the development of chronic and pathological pain in humans and rodent models. Following peripheral nerve injury, neuroimmune signaling within the CNS plays an important role in the pathophysiological changes in pain sensitivity that lead to chronic pain. In production animals, routine husbandry procedures such as tail docking and castration, often involve some degree of inflammation and peripheral nerve injury and consequently may lead to chronic pain. Our understanding of chronic pain in animals is limited by the difficulty in measuring this pathological pain state. In light of this, we have reviewed the current understanding of chronic pain in production animals. We discuss our ability to measure pain and the implications this has on animal welfare and production outcomes. Further research into the neuroimmune interface in production animals will improve our fundamental understanding of chronic pain and better inform human clinical pain management and animal husbandry practices and interventions. Frontiers Media S.A. 2022-05-19 /pmc/articles/PMC9160236/ /pubmed/35663552 http://dx.doi.org/10.3389/fnins.2022.887042 Text en Copyright © 2022 Johnston, Whittaker, Franklin and Hutchinson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Johnston, Charlotte H.
Whittaker, Alexandra L.
Franklin, Samantha H.
Hutchinson, Mark R.
The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals
title The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals
title_full The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals
title_fullStr The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals
title_full_unstemmed The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals
title_short The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals
title_sort neuroimmune interface and chronic pain through the lens of production animals
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160236/
https://www.ncbi.nlm.nih.gov/pubmed/35663552
http://dx.doi.org/10.3389/fnins.2022.887042
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