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Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales
Carbapenemase-producing Enterobacterales (CPE) infection control practices are based on the paradigm that detected carriers in the hospital transmit to other patients who stay in the same ward. The role of plasmid-mediated transmission at population level remains largely unknown. In this retrospecti...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160272/ https://www.ncbi.nlm.nih.gov/pubmed/35650193 http://dx.doi.org/10.1038/s41467-022-30637-5 |
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| author | Marimuthu, Kalisvar Venkatachalam, Indumathi Koh, Vanessa Harbarth, Stephan Perencevich, Eli Cherng, Benjamin Pei Zhi Fong, Raymond Kok Choon Pada, Surinder Kaur Ooi, Say Tat Smitasin, Nares Thoon, Koh Cheng Tambyah, Paul Anantharajah Hsu, Li Yang Koh, Tse Hsien De, Partha Pratim Tan, Thean Yen Chan, Douglas Deepak, Rama Narayana Tee, Nancy Wen Sim Kwa, Andrea Cai, Yiying Teo, Yik-Ying Thevasagayam, Natascha May Prakki, Sai Rama Sridatta Xu, Weizhen Khong, Wei Xin Henderson, David Stoesser, Nicole Eyre, David W. Crook, Derrick Ang, Michelle Lin, Raymond Tzer Pin Chow, Angela Cook, Alex R. Teo, Jeanette Ng, Oon Tek |
| author_facet | Marimuthu, Kalisvar Venkatachalam, Indumathi Koh, Vanessa Harbarth, Stephan Perencevich, Eli Cherng, Benjamin Pei Zhi Fong, Raymond Kok Choon Pada, Surinder Kaur Ooi, Say Tat Smitasin, Nares Thoon, Koh Cheng Tambyah, Paul Anantharajah Hsu, Li Yang Koh, Tse Hsien De, Partha Pratim Tan, Thean Yen Chan, Douglas Deepak, Rama Narayana Tee, Nancy Wen Sim Kwa, Andrea Cai, Yiying Teo, Yik-Ying Thevasagayam, Natascha May Prakki, Sai Rama Sridatta Xu, Weizhen Khong, Wei Xin Henderson, David Stoesser, Nicole Eyre, David W. Crook, Derrick Ang, Michelle Lin, Raymond Tzer Pin Chow, Angela Cook, Alex R. Teo, Jeanette Ng, Oon Tek |
| author_sort | Marimuthu, Kalisvar |
| collection | PubMed |
| description | Carbapenemase-producing Enterobacterales (CPE) infection control practices are based on the paradigm that detected carriers in the hospital transmit to other patients who stay in the same ward. The role of plasmid-mediated transmission at population level remains largely unknown. In this retrospective cohort study over 4.7 years involving all multi-disciplinary public hospitals in Singapore, we analysed 779 patients who acquired CPE (1215 CPE isolates) detected by clinical or surveillance cultures. 42.0% met putative clonal transmission criteria, 44.8% met putative plasmid-mediated transmission criteria and 13.2% were unlinked. Only putative clonal transmissions associated with direct ward contact decreased in the second half of the study. Both putative clonal and plasmid-mediated transmission associated with indirect (no temporal overlap in patients’ admission period) ward and hospital contact did not decrease during the study period. Indirect ward and hospital contact were identified as independent risk factors associated with clonal transmission. In conclusion, undetected CPE reservoirs continue to evade hospital infection prevention measures. New measures are needed to address plasmid-mediated transmission, which accounted for 50% of CPE dissemination. |
| format | Online Article Text |
| id | pubmed-9160272 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91602722022-06-03 Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales Marimuthu, Kalisvar Venkatachalam, Indumathi Koh, Vanessa Harbarth, Stephan Perencevich, Eli Cherng, Benjamin Pei Zhi Fong, Raymond Kok Choon Pada, Surinder Kaur Ooi, Say Tat Smitasin, Nares Thoon, Koh Cheng Tambyah, Paul Anantharajah Hsu, Li Yang Koh, Tse Hsien De, Partha Pratim Tan, Thean Yen Chan, Douglas Deepak, Rama Narayana Tee, Nancy Wen Sim Kwa, Andrea Cai, Yiying Teo, Yik-Ying Thevasagayam, Natascha May Prakki, Sai Rama Sridatta Xu, Weizhen Khong, Wei Xin Henderson, David Stoesser, Nicole Eyre, David W. Crook, Derrick Ang, Michelle Lin, Raymond Tzer Pin Chow, Angela Cook, Alex R. Teo, Jeanette Ng, Oon Tek Nat Commun Article Carbapenemase-producing Enterobacterales (CPE) infection control practices are based on the paradigm that detected carriers in the hospital transmit to other patients who stay in the same ward. The role of plasmid-mediated transmission at population level remains largely unknown. In this retrospective cohort study over 4.7 years involving all multi-disciplinary public hospitals in Singapore, we analysed 779 patients who acquired CPE (1215 CPE isolates) detected by clinical or surveillance cultures. 42.0% met putative clonal transmission criteria, 44.8% met putative plasmid-mediated transmission criteria and 13.2% were unlinked. Only putative clonal transmissions associated with direct ward contact decreased in the second half of the study. Both putative clonal and plasmid-mediated transmission associated with indirect (no temporal overlap in patients’ admission period) ward and hospital contact did not decrease during the study period. Indirect ward and hospital contact were identified as independent risk factors associated with clonal transmission. In conclusion, undetected CPE reservoirs continue to evade hospital infection prevention measures. New measures are needed to address plasmid-mediated transmission, which accounted for 50% of CPE dissemination. Nature Publishing Group UK 2022-06-01 /pmc/articles/PMC9160272/ /pubmed/35650193 http://dx.doi.org/10.1038/s41467-022-30637-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Marimuthu, Kalisvar Venkatachalam, Indumathi Koh, Vanessa Harbarth, Stephan Perencevich, Eli Cherng, Benjamin Pei Zhi Fong, Raymond Kok Choon Pada, Surinder Kaur Ooi, Say Tat Smitasin, Nares Thoon, Koh Cheng Tambyah, Paul Anantharajah Hsu, Li Yang Koh, Tse Hsien De, Partha Pratim Tan, Thean Yen Chan, Douglas Deepak, Rama Narayana Tee, Nancy Wen Sim Kwa, Andrea Cai, Yiying Teo, Yik-Ying Thevasagayam, Natascha May Prakki, Sai Rama Sridatta Xu, Weizhen Khong, Wei Xin Henderson, David Stoesser, Nicole Eyre, David W. Crook, Derrick Ang, Michelle Lin, Raymond Tzer Pin Chow, Angela Cook, Alex R. Teo, Jeanette Ng, Oon Tek Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales |
| title | Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales |
| title_full | Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales |
| title_fullStr | Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales |
| title_full_unstemmed | Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales |
| title_short | Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales |
| title_sort | whole genome sequencing reveals hidden transmission of carbapenemase-producing enterobacterales |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160272/ https://www.ncbi.nlm.nih.gov/pubmed/35650193 http://dx.doi.org/10.1038/s41467-022-30637-5 |
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