Cargando…

Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study

Despite recent studies suggesting a declining incidence and prevalence of dementia on a global scale, epidemiologic results with respect to Alzheimer's disease (AD) are lacking due to the methodological limitations inherent to conducting large-scale cohort investigations of this topic. The aim...

Descripción completa

Detalles Bibliográficos
Autores principales: Baek, Min Seok, Kim, Han-Kyeol, Han, Kyungdo, Kwon, Hyuk-Sung, Na, Han Kyu, Lyoo, Chul Hyoung, Cho, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160364/
https://www.ncbi.nlm.nih.gov/pubmed/35665039
http://dx.doi.org/10.3389/fneur.2022.883549
_version_ 1784719254181904384
author Baek, Min Seok
Kim, Han-Kyeol
Han, Kyungdo
Kwon, Hyuk-Sung
Na, Han Kyu
Lyoo, Chul Hyoung
Cho, Hanna
author_facet Baek, Min Seok
Kim, Han-Kyeol
Han, Kyungdo
Kwon, Hyuk-Sung
Na, Han Kyu
Lyoo, Chul Hyoung
Cho, Hanna
author_sort Baek, Min Seok
collection PubMed
description Despite recent studies suggesting a declining incidence and prevalence of dementia on a global scale, epidemiologic results with respect to Alzheimer's disease (AD) are lacking due to the methodological limitations inherent to conducting large-scale cohort investigations of this topic. The aim of the current study was to investigate the incidence and prevalence of AD in Korea. We conducted a secondary analysis within the National Health Insurance System (NHIS) database, a unique resource that reports medical information for the entire Korean population. AD diagnoses as well as evaluations of vascular risks were defined based on International Statistical Classification of Diseases (ICD-10) codes along with prescription records. The cut-off age for diagnosing AD was defined as the age of the patient's highest Youden index. In this study, the incidence and prevalence of AD in the Korean population aged 40 years or older showed an overall increase between 2006 and 2015. Although both older and younger age groups showed an increase in the incidence and prevalence of AD, the highest increase was observed in older age groups. Based on the highest Youden's index value (sensitivity + specificity – 1), the cut-off value for the diagnosis of AD was 69 years with an area under the curve (AUC) of 0.92. We found that the incidence of AD was higher in individuals with underlying vascular risks. However, in recent years, the prevalence of AD was conversely found to be lower in individuals with hypertension or dyslipidemia. Despite efforts toward reducing the number of AD cases through educational, policy, and various public health and preventive medicine interventions, the incidence and prevalence of AD continues to grow in Korea. Efforts aimed at early diagnosis and the modification of underlying risks may be critical to reducing the socioeconomic burden of AD.
format Online
Article
Text
id pubmed-9160364
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91603642022-06-03 Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study Baek, Min Seok Kim, Han-Kyeol Han, Kyungdo Kwon, Hyuk-Sung Na, Han Kyu Lyoo, Chul Hyoung Cho, Hanna Front Neurol Neurology Despite recent studies suggesting a declining incidence and prevalence of dementia on a global scale, epidemiologic results with respect to Alzheimer's disease (AD) are lacking due to the methodological limitations inherent to conducting large-scale cohort investigations of this topic. The aim of the current study was to investigate the incidence and prevalence of AD in Korea. We conducted a secondary analysis within the National Health Insurance System (NHIS) database, a unique resource that reports medical information for the entire Korean population. AD diagnoses as well as evaluations of vascular risks were defined based on International Statistical Classification of Diseases (ICD-10) codes along with prescription records. The cut-off age for diagnosing AD was defined as the age of the patient's highest Youden index. In this study, the incidence and prevalence of AD in the Korean population aged 40 years or older showed an overall increase between 2006 and 2015. Although both older and younger age groups showed an increase in the incidence and prevalence of AD, the highest increase was observed in older age groups. Based on the highest Youden's index value (sensitivity + specificity – 1), the cut-off value for the diagnosis of AD was 69 years with an area under the curve (AUC) of 0.92. We found that the incidence of AD was higher in individuals with underlying vascular risks. However, in recent years, the prevalence of AD was conversely found to be lower in individuals with hypertension or dyslipidemia. Despite efforts toward reducing the number of AD cases through educational, policy, and various public health and preventive medicine interventions, the incidence and prevalence of AD continues to grow in Korea. Efforts aimed at early diagnosis and the modification of underlying risks may be critical to reducing the socioeconomic burden of AD. Frontiers Media S.A. 2022-05-19 /pmc/articles/PMC9160364/ /pubmed/35665039 http://dx.doi.org/10.3389/fneur.2022.883549 Text en Copyright © 2022 Baek, Kim, Han, Kwon, Na, Lyoo and Cho. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Baek, Min Seok
Kim, Han-Kyeol
Han, Kyungdo
Kwon, Hyuk-Sung
Na, Han Kyu
Lyoo, Chul Hyoung
Cho, Hanna
Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
title Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
title_full Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
title_fullStr Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
title_full_unstemmed Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
title_short Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
title_sort annual trends in the incidence and prevalence of alzheimer's disease in south korea: a nationwide cohort study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160364/
https://www.ncbi.nlm.nih.gov/pubmed/35665039
http://dx.doi.org/10.3389/fneur.2022.883549
work_keys_str_mv AT baekminseok annualtrendsintheincidenceandprevalenceofalzheimersdiseaseinsouthkoreaanationwidecohortstudy
AT kimhankyeol annualtrendsintheincidenceandprevalenceofalzheimersdiseaseinsouthkoreaanationwidecohortstudy
AT hankyungdo annualtrendsintheincidenceandprevalenceofalzheimersdiseaseinsouthkoreaanationwidecohortstudy
AT kwonhyuksung annualtrendsintheincidenceandprevalenceofalzheimersdiseaseinsouthkoreaanationwidecohortstudy
AT nahankyu annualtrendsintheincidenceandprevalenceofalzheimersdiseaseinsouthkoreaanationwidecohortstudy
AT lyoochulhyoung annualtrendsintheincidenceandprevalenceofalzheimersdiseaseinsouthkoreaanationwidecohortstudy
AT chohanna annualtrendsintheincidenceandprevalenceofalzheimersdiseaseinsouthkoreaanationwidecohortstudy