Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom

Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter ot...

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Detalles Bibliográficos
Autores principales: Emidio, Beraldo-Neto, Ivo, Lebrun, Leonor Abrahao, Nencioni Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Toxins from venomous and poisonous animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160406/
https://www.ncbi.nlm.nih.gov/pubmed/35663624
http://dx.doi.org/10.1016/j.toxcx.2022.100126
Descripción
Sumario:Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter other neurotransmitters. Thus, dopaminergic system seems to be partially responsible for the convulsive process. Specific action on particular neurotransmitter can make this toxin a useful tool to better understand the functioning of the system.

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