Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom

Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter ot...

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Detalles Bibliográficos
Autores principales: Emidio, Beraldo-Neto, Ivo, Lebrun, Leonor Abrahao, Nencioni Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Toxins from venomous and poisonous animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160406/
https://www.ncbi.nlm.nih.gov/pubmed/35663624
http://dx.doi.org/10.1016/j.toxcx.2022.100126
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author Emidio, Beraldo-Neto
Ivo, Lebrun
Leonor Abrahao, Nencioni Ana
author_facet Emidio, Beraldo-Neto
Ivo, Lebrun
Leonor Abrahao, Nencioni Ana
author_sort Emidio, Beraldo-Neto
collection PubMed
description Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter other neurotransmitters. Thus, dopaminergic system seems to be partially responsible for the convulsive process. Specific action on particular neurotransmitter can make this toxin a useful tool to better understand the functioning of the system.
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spelling pubmed-91604062022-06-03 Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom Emidio, Beraldo-Neto Ivo, Lebrun Leonor Abrahao, Nencioni Ana Toxicon X Toxins from venomous and poisonous animal Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter other neurotransmitters. Thus, dopaminergic system seems to be partially responsible for the convulsive process. Specific action on particular neurotransmitter can make this toxin a useful tool to better understand the functioning of the system. Elsevier 2022-05-27 /pmc/articles/PMC9160406/ /pubmed/35663624 http://dx.doi.org/10.1016/j.toxcx.2022.100126 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Toxins from venomous and poisonous animal
Emidio, Beraldo-Neto
Ivo, Lebrun
Leonor Abrahao, Nencioni Ana
Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom
title Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom
title_full Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom
title_fullStr Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom
title_full_unstemmed Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom
title_short Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom
title_sort dopaminergic metabolism is affected by intracerebral injection of tb ii-i isolated from tityus bahiensis scorpion venom
topic Toxins from venomous and poisonous animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160406/
https://www.ncbi.nlm.nih.gov/pubmed/35663624
http://dx.doi.org/10.1016/j.toxcx.2022.100126
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