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Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis

BACKGROUNDS: There were conflicting results on the comparison of brain-derived neurotrophic factor (BDNF) levels between poststroke depression (PSD) patients and stroke patients without PSD among previous studies. Thus, we conducted this systemic review and meta-analysis to explore the alteration of...

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Autores principales: Zhang, Chunhui, Wang, Xuefang, Zhu, Qinghua, Mei, Yongxia, Zhang, Zhenxiang, Xu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160429/
https://www.ncbi.nlm.nih.gov/pubmed/35664480
http://dx.doi.org/10.3389/fpsyt.2022.876557
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author Zhang, Chunhui
Wang, Xuefang
Zhu, Qinghua
Mei, Yongxia
Zhang, Zhenxiang
Xu, Hui
author_facet Zhang, Chunhui
Wang, Xuefang
Zhu, Qinghua
Mei, Yongxia
Zhang, Zhenxiang
Xu, Hui
author_sort Zhang, Chunhui
collection PubMed
description BACKGROUNDS: There were conflicting results on the comparison of brain-derived neurotrophic factor (BDNF) levels between poststroke depression (PSD) patients and stroke patients without PSD among previous studies. Thus, we conducted this systemic review and meta-analysis to explore the alteration of serum BDNF levels in PSD. METHODS: This study included articles from the Web of Science and PubMed databases that were published before December 2021. STATA 12.0 software was used to compute the standardized mean difference (SMD) and 95% confidence interval (CI) regarding the comparison of serum BDNF in PSD and stroke patients without PSD. RESULTS: We collected the mean value and standard deviation (SD) of serum BDNF in PSD and stroke patients without PSD from six studies (PSD: n = 268, stroke patients without PSD: n = 425). The present meta-analysis showed decreased serum BDNF level in patients with PSD, compared to stroke patients without PSD with a random-effects model (mean value of BDNF level [PSD vs. stroke patients without PSD]: 14.106 vs. 17.995 ng/ml; SMD = –1.578; 95% CI: –2.820, –0.337; I(2) = 97.8%, p-value for Q test < 0.001). CONCLUSION: Brain-derived neurotrophic factor may work as a potential biomarker to predict the risk of PSD among stroke survivors. More large-sample clinical trials exploring the alteration of serum BDNF levels in PSD among stroke patients need to be conducted to verify this result.
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spelling pubmed-91604292022-06-03 Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis Zhang, Chunhui Wang, Xuefang Zhu, Qinghua Mei, Yongxia Zhang, Zhenxiang Xu, Hui Front Psychiatry Psychiatry BACKGROUNDS: There were conflicting results on the comparison of brain-derived neurotrophic factor (BDNF) levels between poststroke depression (PSD) patients and stroke patients without PSD among previous studies. Thus, we conducted this systemic review and meta-analysis to explore the alteration of serum BDNF levels in PSD. METHODS: This study included articles from the Web of Science and PubMed databases that were published before December 2021. STATA 12.0 software was used to compute the standardized mean difference (SMD) and 95% confidence interval (CI) regarding the comparison of serum BDNF in PSD and stroke patients without PSD. RESULTS: We collected the mean value and standard deviation (SD) of serum BDNF in PSD and stroke patients without PSD from six studies (PSD: n = 268, stroke patients without PSD: n = 425). The present meta-analysis showed decreased serum BDNF level in patients with PSD, compared to stroke patients without PSD with a random-effects model (mean value of BDNF level [PSD vs. stroke patients without PSD]: 14.106 vs. 17.995 ng/ml; SMD = –1.578; 95% CI: –2.820, –0.337; I(2) = 97.8%, p-value for Q test < 0.001). CONCLUSION: Brain-derived neurotrophic factor may work as a potential biomarker to predict the risk of PSD among stroke survivors. More large-sample clinical trials exploring the alteration of serum BDNF levels in PSD among stroke patients need to be conducted to verify this result. Frontiers Media S.A. 2022-05-19 /pmc/articles/PMC9160429/ /pubmed/35664480 http://dx.doi.org/10.3389/fpsyt.2022.876557 Text en Copyright © 2022 Zhang, Wang, Zhu, Mei, Zhang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Zhang, Chunhui
Wang, Xuefang
Zhu, Qinghua
Mei, Yongxia
Zhang, Zhenxiang
Xu, Hui
Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis
title Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis
title_full Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis
title_fullStr Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis
title_full_unstemmed Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis
title_short Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis
title_sort decreased serum brain-derived neurotrophic factor in poststroke depression: a systematic review and meta-analysis
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160429/
https://www.ncbi.nlm.nih.gov/pubmed/35664480
http://dx.doi.org/10.3389/fpsyt.2022.876557
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