Targeting AKT and CK2 represents a novel therapeutic strategy for SMO constitutive activation‐driven medulloblastoma

AIMS: Sonic hedgehog subtype medulloblastoma is featured with overactivation of hedgehog pathway and can be targeted by SMO‐specific inhibitors. However, the resistance is frequently developed leading to treatment failure of SMO inhibitors. W535L mutation of SMO (SMO(W535L)) is thought to be an onco...

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Detalles Bibliográficos
Autores principales: Yao, Yue‐Liang, Wang, Yan‐Xia, Yang, Fei‐Cheng, Wang, Chuan, Mao, Min, Gai, Qu‐Jing, He, Jiang, Qin, Yan, Yao, Xiao‐Xue, Lan, Xi, Zhu, Jiang, Lu, Hui‐Min, Zeng, Hui, Yao, Xiao‐Hong, Bian, Xiu‐Wu, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160449/
https://www.ncbi.nlm.nih.gov/pubmed/35419951
http://dx.doi.org/10.1111/cns.13835

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